Congenital adrenal hyperplasia—current insights in pathophysiology, diagnostics, and management

HL Claahsen-van der Grinten, PW Speiser… - Endocrine …, 2022 - academic.oup.com
Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders affecting
cortisol biosynthesis. Reduced activity of an enzyme required for cortisol production leads to …

Management challenges and therapeutic advances in congenital adrenal hyperplasia

A Mallappa, DP Merke - Nature Reviews Endocrinology, 2022 - nature.com
Abstract Treatment for congenital adrenal hyperplasia (CAH) was introduced in the 1950s
following the discovery of the structure and function of adrenocortical hormones. Although …

Basics of androgen synthesis and action

RN Elzenaty, T Du Toit, CE Flück - Best Practice & Research Clinical …, 2022 - Elsevier
Androgens are essential sex steroid hormones for both sexes. Testosterone (T) is the
predominant androgen in males, while in adult females, T concentrations are about 15-fold …

Insulin resistance and PCOS: chicken or egg?

P Moghetti, F Tosi - Journal of endocrinological investigation, 2021 - Springer
PCOS is a common and heterogeneous endocrine disorder in women of reproductive age,
frequently associated with metabolic abnormalities. It was estimated that about 75% of these …

The roles of androgens in humans: biology, metabolic regulation and health

M Alemany - International journal of molecular sciences, 2022 - mdpi.com
Androgens are an important and diverse group of steroid hormone molecular species. They
play varied functional roles, such as the control of metabolic energy fate and partition, the …

Considering sex as a biological variable in basic and clinical studies: an endocrine society scientific statement

A Bhargava, AP Arnold, DA Bangasser… - Endocrine …, 2021 - academic.oup.com
Abstract In May 2014, the National Institutes of Health (NIH) stated its intent to “require
applicants to consider sex as a biological variable (SABV) in the design and analysis of NIH …

Hormones and aging: an endocrine society scientific statement

AR Cappola, RJ Auchus… - The Journal of …, 2023 - academic.oup.com
Multiple changes occur across various endocrine systems as an individual ages. The
understanding of the factors that cause age-related changes and how they should be …

11-Oxygenated androgens in health and disease

AF Turcu, J Rege, RJ Auchus, WE Rainey - Nature Reviews …, 2020 - nature.com
The adrenal gland is a source of sex steroid precursors, and its activity is particularly
relevant during fetal development and adrenarche. Following puberty, the synthesis of …

Normal and premature adrenarche

RL Rosenfield - Endocrine reviews, 2021 - academic.oup.com
Adrenarche is the maturational increase in adrenal androgen production that normally
begins in early childhood. It results from changes in the secretory response to …

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency

DP Merke, RJ Auchus - New England Journal of Medicine, 2020 - Mass Medical Soc
CAH Due to 21-Hydroxylase Deficiency Congenital adrenal hyperplasia, a common
autosomal recessive disorder, is potentially life-threatening in its classic form and may be …