Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

The cytochrome P450 monooxygenases (P450s) are thiolate heme proteins that can, often
under physiological conditions, catalyze many distinct oxidative transformations on a wide …

The human cytochrome P450 17A1 (CYP17A1) enzyme operates at a key juncture of human
steroidogenesis, controlling the levels of mineralocorticoids influencing blood pressure …

Rufomycins constitute a class of cyclic heptapeptides isolated from actinomycetes. They are
secondary metabolites that show promising treatment against Mycobacterium tuberculosis …

CYP19A1, or aromatase, a cytochrome P450 responsible for estrogen biosynthesis in
humans, is an important therapeutic target for the treatment of breast cancer. There is still …

Abstract Cytochrome P450 17A1 (CYP17A1) is an important drug target for castration
resistant prostate cancer. It is a bi-functional enzyme, catalyzing production of glucocorticoid …

The complex multistep mechanism of oxygen activation in P450 is reviewed as a sequence
of the following reactions: Substrate binding, reduction of the heme iron from ferric to the …

Abstract Cytochrome P450 CYP3A4 is the main drug-metabolizing enzyme in the human
liver, being responsible for oxidation of 50% of all pharmaceuticals metabolized by human …

Heme-based sensor proteins are used by organisms to control signaling and physiological
effects in response to their gaseous environment. Globin-coupled sensors (GCS) are oxygen …

Cytochrome c oxidase (CcO) reduces O 2, pumps protons in the mitochondrial respiratory
chain, and is essential for oxygen consumption in the cell. The coiled-coil-helix-coiled-coil …