The non-classical nucleation of crystals: microscopic mechanisms and applications to molecular crystals, ice and calcium carbonate

RP Sear - International Materials Reviews, 2012 - Taylor & Francis
Crystals form via nucleation followed by growth. Often nucleation data are interpreted using
the classical theory of nucleation, which is essentially a simple theory for the nucleation of a …

Surface-induced crystallization of pharmaceuticals and biopharmaceuticals: A review

F Artusio, R Pisano - International journal of pharmaceutics, 2018 - Elsevier
Despite the wide occurrence of crystallization in the pharmaceutical industry, deep
understanding and fine control of the process remain a tricky issue. Nevertheless, the …

Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme

H Wei, Z Wang, J Zhang, S House, YG Gao… - Nature …, 2011 - nature.com
Gold nanoparticles are useful in biomedical applications due to their distinct optical
properties and high chemical stability,,,,. Reports of the biogenic formation of gold colloids …

A workflow for the development of template-assisted membrane crystallization downstream processing for monoclonal antibody purification

N Rajoub, CJJ Gerard, E Pantuso, E Fontananova… - Nature …, 2023 - nature.com
Monoclonal antibodies (mAbs) are commonly used biologic drugs for the treatment of
diseases such as rheumatoid arthritis, multiple sclerosis, COVID-19 and various cancers …

Radiation stability and photothermal performance of surface-functionalized plasmonic nanofluids for direct-absorption solar applications

OZ Sharaf, N Rizk, CJ Munro, CP Joshi… - Solar Energy Materials …, 2021 - Elsevier
In this work, the photostability of gold nanoparticles (AuNPs) with different functional
molecular coatings was investigated. Gold/water nanofluids were prepared using citrate …

Heterogeneous nucleation in protein crystallization

H Liu, Y Zhao, J Sun - Biomimetics, 2023 - mdpi.com
Protein crystallization was first discovered in the nineteenth century and has been studied
for nearly 200 years. Protein crystallization technology has recently been widely used in …

High protein-loading silica template for heterogeneous protein crystallization

W Chen, SJ Park, F Kong, X Li, H Yang… - Crystal Growth & …, 2019 - ACS Publications
As a purification technology, crystallization is advantageous over chromatography and
precipitation in terms of purity, cost, and scalability. In general, proteins have slow …

Gold nanoparticles and bioconjugation: A pathway for proteomic applications

C Couto, R Vitorino… - Critical reviews in …, 2017 - Taylor & Francis
In the last few years gold nanoparticles (AuNPs) became extremely interesting materials due
to their enhanced optical, chemical and electrical properties. With the intention of taking …

Protein purification with nanoparticle-enhanced crystallisation

W Chen, TNH Cheng, LF Khaw, X Li, H Yang… - Separation and …, 2021 - Elsevier
In this study, silica nanoparticle was synthesised and used to promote lysozyme
crystallisation effectively against high concentrations of protein impurity (bovine serum …

Carbon-nanotube-based materials for protein crystallization

P Asanithi, E Saridakis, L Govada… - … Applied Materials & …, 2009 - ACS Publications
We report on the first use of carbon-nanotube-based films to produce crystals of proteins.
The crystals nucleate on the surface of the film. The difficulty of crystallizing proteins is a …