Cancer cells subvert multiple properties of normal cells, including escaping strict cell cycle
regulation, gaining resistance to cell death, and remodeling the tumor microenvironment …

Aging is a major risk factor for many diseases. Recent studies have shown that age-related
disruption of proteostasis leads to the accumulation of abnormal proteins and that …

The chiral 2× 2 charge order has been reported and confirmed in the kagome
superconductor RbV 3 Sb 5, while its interplay with superconductivity remains elusive owing …

The retina is light-sensitive neuronal tissue in the back of the eye. The phospholipid
composition of the retina is unique and highly enriched in polyunsaturated fatty acids …

The importance of redox systems as fundamental elements in biology is now widely
recognized across diverse fields, from ecology to cellular biology. Their connection to …

Neurodegenerative diseases are characterized by the presence of misfolded and
aggregated proteins which are thought to contribute to the development of the disease. In …

Endothelial cells (ECs) display organ-and tissue-specific heterogeneity. In the eye, the
retinal and choroidal vascular beds are distinct networks with different molecular and …

Rapid recovery of proteasome activity may contribute to intrinsic and acquired resistance to
FDA-approved proteasome inhibitors. Previous studies have demonstrated that the …

The 26S proteasome degrades the majority of cellular proteins and affects all aspects of
cellular life. Therefore, the 26S proteasome abundance, proper assembly, and activity in …

The cellular response to a decrease in protein degradation by 26S proteasomes in chronic
diseases is poorly understood. Pharmacological inhibition of proteasomes increases the …