DNA is vulnerable to damage resulting from endogenous metabolites, environmental and
dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …

DNA damaging agents are potent inducers of cell death triggered by apoptosis. Since these
agents induce a plethora of different DNA lesions, it is firstly important to identify the specific …

Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for
some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and …

The activation of nuclear factor-kappaB (NFΚB), a proinflammatory transcription factor, is a
commonly observed phenomenon in breast cancer. It facilitates the development of a …

The NF-κB pathway is a ubiquitous stress response that activates the NF-κB family of
transcription factors. Antigen receptors, receptors of the innate immune system, and certain …

De novo resistance and rapid recurrence often characterize responses of B-cell
malignancies to ibrutinib (IBR), indicating a need to develop drug combinations that block …

Second mitochondria-derived activator of caspase (Smac) is a mitochondrial protein
released into the cytosol during apoptosis. Smac mimetics have recently been touted as a …

Abstract Hypoxia-inducible factor-1alpha (HIF-1alpha) is important for adaptation to hypoxia.
Hypoxia is a common feature of cancer and inflammation, by which HIF-1alpha increases …

The Wnt/β-catenin pathway is involved in diverse cell functions governing development and
disease. β-Catenin, a central mediator of this pathway, binds to members of the TCF/LEF …

BACKGROUND: Due to its antioxidant and anti-inflammatory properties, hydrogen gas (H2)
has protective effects on a variety of organs from damage induced by ischemia/reperfusion …