TIMPs: versatile extracellular regulators in cancer

HW Jackson, V Defamie, P Waterhouse… - Nature Reviews …, 2017 - nature.com
A compelling long-term goal of cancer biology is to understand the crucial players during
tumorigenesis in order to develop new interventions. Here, we review how the four non …

New concepts in cancer biomarkers: circulating miRNAs in liquid biopsies

E Larrea, C Sole, L Manterola, I Goicoechea… - International journal of …, 2016 - mdpi.com
The effective and efficient management of cancer patients relies upon early diagnosis and/or
the monitoring of treatment, something that is often difficult to achieve using standard tissue …

Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth

Y Shi, YF Ping, W Zhou, ZC He, C Chen… - Nature …, 2017 - nature.com
Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of
glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report …

Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization

Z Li, WJ Fu, XQ Chen, S Wang, RS Deng… - Journal of Experimental …, 2022 - Springer
Background Glioblastoma (GB) is the most common and highly malignant brain tumor
characterized by aggressive growth and resistance to alkylating chemotherapy. Autophagy …

CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling

X Zhang, L Chen, W Dang, M Cao, J Xiao, S Lv… - Laboratory …, 2020 - nature.com
Tumor-associated macrophages (TAMs) constitute a large population of glioblastoma and
facilitate tumor growth and invasion of tumor cells, but the underlying mechanism remains …

MicroRNAs in glioblastoma multiforme pathogenesis and therapeutics

A Shea, V Harish, Z Afzal, J Chijioke, H Kedir… - Cancer …, 2016 - Wiley Online Library
Glioblastoma multiforme (GBM) is the most common and lethal cancer of the adult brain,
remaining incurable with a median survival time of only 15 months. In an effort to identify …

Signaling pathways governing glioma cancer stem cells behavior

A Nasrolahi, S Azizidoost, K Radoszkiewicz, S Najafi… - Cellular …, 2023 - Elsevier
Glioma is the most common malignant brain tumor that develops in the glial tissue. Several
studies have identified that glioma cancer stem cells (GCSCs) play important roles in tumor …

[HTML][HTML] Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells

LL Fang, XH Wang, BF Sun… - International …, 2017 - spandidos-publications.com
MicroRNAs (miRNAs), a class of short, single‑stranded non‑coding RNAs, regulate and
control gene expression in eukaryotes by degrading mRNA at the post‑transcriptional level …

Non-coding RNAs and glioblastoma: Insight into their roles in metastasis

SM Mousavi, M Derakhshan, F Baharloii… - Molecular Therapy …, 2022 - cell.com
Glioma, also known as glioblastoma multiforme (GBM), is the most prevalent and most lethal
primary brain tumor in adults. Gliomas are highly invasive tumors with the highest death rate …

MIR106A-5p upregulation suppresses autophagy and accelerates malignant phenotype in nasopharyngeal carcinoma

Q Zhu, Q Zhang, M Gu, K Zhang, T Xia, S Zhang… - Autophagy, 2021 - Taylor & Francis
Dysregulated microRNAs (miRNAs) are involved in carcinoma progression, metastasis, and
poor prognosis. We demonstrated that in nasopharyngeal carcinoma (NPC), transactivated …