Bile acids impact the microbiota, host, and C. difficile dynamics providing insight into mechanisms of efficacy of FMTs and microbiota-focused therapeutics
AS McMillan, CM Theriot - Gut Microbes, 2024 - Taylor & Francis
Clostridioides difficile is a major nosocomial pathogen, causing significant morbidity and
mortality worldwide. Antibiotic usage, a major risk factor for Clostridioides difficile infection …
mortality worldwide. Antibiotic usage, a major risk factor for Clostridioides difficile infection …
[PDF][PDF] Cyclic-di-AMP signalling in lactic acid bacteria
Cyclic dimeric adenosine monophosphate (cyclic-di-AMP) is a nucleotide second
messenger present in Gram-positive bacteria, Gram-negative bacteria and some Archaea …
messenger present in Gram-positive bacteria, Gram-negative bacteria and some Archaea …
The multiplicity of thioredoxin systems meets the specific lifestyles of Clostridia
Cells are unceasingly confronted by oxidative stresses that oxidize proteins on their
cysteines. The thioredoxin (Trx) system, which is a ubiquitous system for thiol and protein …
cysteines. The thioredoxin (Trx) system, which is a ubiquitous system for thiol and protein …
Molecular mechanism of Phoebe bournei essential oils inhibiting the survival of Staphylococcus aureus and Bacillus cereus
L Liu, L Ji, Y Lai, L Yang, G He, D Zhang - Industrial Crops and Products, 2023 - Elsevier
The essential oils (EOs) from twigs and leaves of the clonal P. bournei are great natural
antibacterial agents with strong inhibition against Bacillus cereus and Staphylococcus …
antibacterial agents with strong inhibition against Bacillus cereus and Staphylococcus …
Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and …
Antivirulence agents targeting endospore-transmitted Clostridioides difficile infections are
urgently needed. C. difficile-specific DNA adenine methyltransferase (CamA) is required for …
urgently needed. C. difficile-specific DNA adenine methyltransferase (CamA) is required for …
Cyclic di-AMP, a multifaceted regulator of central metabolism and osmolyte homeostasis in Listeria monocytogenes
I Schwedt, M Wang, J Gibhardt, FM Commichau - Microlife, 2023 - academic.oup.com
Cyclic di-AMP is an emerging second messenger that is synthesized by many archaea and
bacteria, including the Gram-positive pathogenic bacterium Listeria monocytogenes. Listeria …
bacteria, including the Gram-positive pathogenic bacterium Listeria monocytogenes. Listeria …
Potent Bile Acid Microbial Metabolites Modulate Clostridium perfringens Virulence
Clostridium perfringens is a versatile pathogen, inducing diseases in the skin, intestine
(such as chicken necrotic enteritis (NE)), and other organs. The classical sign of NE is the …
(such as chicken necrotic enteritis (NE)), and other organs. The classical sign of NE is the …
[HTML][HTML] Extracellular succinate induces spatially organized biofilm formation in Clostridioides difficile
E Auria, J Deschamps, R Briandet, B Dupuy - Biofilm, 2023 - Elsevier
Clostridioides difficile infection associated to gut microbiome dysbiosis is the leading cause
for nosocomial diarrhea. The ability of C. difficile to form biofilms has been progressively …
for nosocomial diarrhea. The ability of C. difficile to form biofilms has been progressively …
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile
A Malik, A Oludiran, A Poudel, OB Alvarez… - …, 2024 - microbiologyresearch.org
The bacterial stringent response (SR) is a conserved transcriptional reprogramming
pathway mediated by the nucleotide signalling alarmones,(pp) pGpp. The SR has been …
pathway mediated by the nucleotide signalling alarmones,(pp) pGpp. The SR has been …
Expanding our grasp of two-component signaling in Clostridioides difficile
O Berumen Alvarez, EB Purcell - Journal of Bacteriology, 2023 - Am Soc Microbiol
The intestinal pathogen Clostridioides difficile encodes roughly 50 TCS, but very few have
been characterized in terms of their activating signals or their regulatory roles. AG Pannullo …
been characterized in terms of their activating signals or their regulatory roles. AG Pannullo …