IOP and glaucoma damage: The essential role of optic nerve head and retinal mechanosensors
There are many unanswered questions on the relation of intraocular pressure to glaucoma
development and progression. IOP itself cannot be distilled to a single, unifying value …
development and progression. IOP itself cannot be distilled to a single, unifying value …
[HTML][HTML] In vivo corneal elastography: A topical review of challenges and opportunities
Clinical measurement of corneal biomechanics can aid in the early diagnosis, progression
tracking, and treatment evaluation of ocular diseases. Over the past two decades …
tracking, and treatment evaluation of ocular diseases. Over the past two decades …
The strain response to intraocular pressure decrease in the lamina cribrosa of patients with glaucoma
CA Czerpak, MS Kashaf, BK Zimmerman… - Ophthalmology …, 2023 - Elsevier
Objective To measure biomechanical strains in the lamina cribrosa (LC) of living human
eyes with intraocular pressure (IOP) lowering. Design Cohort study. Participants Patients …
eyes with intraocular pressure (IOP) lowering. Design Cohort study. Participants Patients …
In vivo characterization of the deformation of the human optic nerve head using optical coherence tomography and digital volume correlation
We developed a method to measure the 3-dimensional (3D) strain field in the optic nerve
head (ONH) in vivo between two intraocular pressures (IOP). Radial optical coherence …
head (ONH) in vivo between two intraocular pressures (IOP). Radial optical coherence …
Differing associations between optic nerve head strains and visual field loss in patients with normal-and high-tension glaucoma
Purpose To study the associations between optic nerve head (ONH) strains under
intraocular pressure (IOP) elevation with retinal sensitivity in patients with glaucoma. Design …
intraocular pressure (IOP) elevation with retinal sensitivity in patients with glaucoma. Design …
[HTML][HTML] The effects of glaucoma on the pressure-induced strain response of the human lamina cribrosa
Purpose: To measure the ex vivo pressure-induced strain response of the human optic
nerve head and analyze for variations with glaucoma diagnosis and optic nerve axon …
nerve head and analyze for variations with glaucoma diagnosis and optic nerve axon …
The inflation response of the human lamina cribrosa and sclera: Analysis of deformation and interaction
This study investigated the inflation response of the lamina cribrosa (LC) and adjacent
peripapillary sclera (PPS) in post-mortem human eyes with no history of glaucoma. The …
peripapillary sclera (PPS) in post-mortem human eyes with no history of glaucoma. The …
The role of lamina cribrosa tissue stiffness and fibrosis as fundamental biomechanical drivers of pathological glaucoma cupping
AA Hopkins, R Murphy, M Irnaten… - … of Physiology-Cell …, 2020 - journals.physiology.org
The primary biomechanical driver of pathological glaucomatous cupping remains unknown.
Finite element modeling indicates that stress and strain play key roles. In this article …
Finite element modeling indicates that stress and strain play key roles. In this article …
[HTML][HTML] Variation of peripapillary scleral shape with age
Purpose: To define the shape of the anterior surface of the peripapillary sclera (PPS) and
evaluate its relationship with age and ocular determinants in a population-based Chinese …
evaluate its relationship with age and ocular determinants in a population-based Chinese …
Evidence of an Annexin A4 mediated plasma membrane repair response to biomechanical strain associated with glaucoma pathogenesis
N Vicic, X Guo, D Chan, JG Flanagan… - Journal of cellular …, 2022 - Wiley Online Library
Glaucoma is a common neurodegenerative blinding disease that is closely associated with
chronic biomechanical strain at the optic nerve head (ONH). Yet, the cellular injury and …
chronic biomechanical strain at the optic nerve head (ONH). Yet, the cellular injury and …