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The intraocular pressure rise that can complicate the use of topical or systemic corticosteroid
has been recognised for 50 years. More recently, following isolation of the myocilin gene …

Corticosteroids, used prudently, are one of the most potent and effective modalities available
in the treatment of ocular inflammation. However, they can produce a plethora of adverse …

Glucocorticoid effects on the human trabecular meshwork can be used as a model system in
which to study glaucomatous damage to the trabecular meshwork. One of the most important …

Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy
triggered by both environmental and genetic risk factors. Several ocular tissues, including …

Expression of the trabecular meshwork inducible glucocorticoid response (TIGR) gene
progressively increases from barely detectable levels to greater than 2% of total cellular …

A map of 30,181 human gene–based markers was assembled and integrated with the
current genetic map by radiation hybrid mapping. The new gene map contains nearly twice …

Corticosteroids (glucocorticoids), used frequently as potent anti-inflammatory agents,
increase the risk of glaucoma by raising the intraocular pressure (IOP) when administered …

Genetic factors have long been implicated in the pathophysiology of primary open-angle
glaucoma (POAG). Recently, myocilin, a gene of unknown function, was associated with …

Mutations in the MYOC gene that encodes for myocilin are causative for some forms of
juvenile and adult-onset primary open-angle glaucoma (POAG). Myocilin is a secreted 55 …