Context.—Next-generation sequencing (NGS) is a technology being used by many
laboratories to test for inherited disorders and tumor mutations. This technology is new for …

Technological innovation and rapid reduction in sequencing costs have enabled the
genomic profiling of hundreds of cancer-associated genes as a component of routine cancer …

CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in
Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of …

Next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) supports blood-based
genomic profiling but is not yet routinely implemented in the setting of a phase I trials clinic …

We developed and clinically validated a hybrid capture next generation sequencing assay to
detect somatic alterations and microsatellite instability in solid tumors and hematologic …

Precision oncology relies on accurate discovery and interpretation of genomic variants,
enabling individualized diagnosis, prognosis and therapy selection. We found that six …

Precision cancer medicine (PCM) is a concept in which oncologists increasingly strive to
tailor the use of targeted therapies in order to match the complexity of the cancer genome …

Background To promote precision oncology in clinical practice, the Japanese Society of
Medical Oncology, the Japanese Society of Clinical Oncology, and the Japanese Cancer …

Next‐generation sequencing has become a cornerstone of therapy guidance in cancer
precision medicine and an indispensable research tool in translational oncology. Its rapidly …

Abstract CIViC (Clinical Interpretation of Variants in Cancer; civicdb. org) is a crowd-sourced,
public domain knowledgebase composed of literature-derived evidence characterizing the …