Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Cell death and immune response are at the core of life. In past decades, the endoplasmic
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …

Cancers arise through the accumulation of genetic and epigenetic alterations that enable
cells to evade telomere-based proliferative barriers and achieve immortality. One such …

Replicative crisis is a senescence-independent process that acts as a final barrier against
oncogenic transformation by eliminating pre-cancerous cells with disrupted cell cycle …

The correct duplication and transmission of genetic material to daughter cells is the primary
objective of the cell division cycle. DNA replication and chromosome segregation present …

The shortening of human telomeres has two opposing effects during cancer development.
On the one hand, telomere shortening can exert a tumour-suppressive effect through the …

Telomeres maintain genomic integrity in normal cells, and their progressive shortening
during successive cell divisions induces chromosomal instability. In the large majority of …

Pathogenic and other cytoplasmic DNAs activate the cyclic GMP-AMP synthase (cGAS)-
stimulator of interferon genes (STING) pathway to induce inflammation via transcriptional …

Telomeres, the protective ends of linear chromosomes, shorten throughout an individual's
lifetime. Telomere shortening is proposed to be a primary molecular cause of aging. Short …

Natural chromosome ends resemble double-stranded DNA breaks, but they do not activate
a damage response in healthy cells. Telomeres therefore have evolved to solve the'end …