GABAergic inhibitory circuits play an essential role in coordinating various hippocampal
functions. Several decades of work dedicated to a thorough characterization of hippocampal …

Hebb postulated that, to store information in the brain, assemblies of excitatory neurons
coding for a percept are bound together via associative long-term synaptic plasticity. In this …

Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …

Neocortex is classically divided into distinct areas, each specializing in different function, but
all could benefit from reinforcement feedback to inform and update local processing. Yet it …

Flexibly selecting appropriate actions in response to complex, ever-changing environments
requires both cortical and subcortical regions, which are typically described as participating …

Mammalian cortex features a vast diversity of neuronal cell types, each with characteristic
anatomical, molecular and functional properties. Synaptic connectivity powerfully shapes …

Abstract Cortical GABAergic interneurons (INs) represent a diverse population of mainly
locally projecting cells that provide specialized forms of inhibition to pyramidal neurons and …

Stimulus-selective response plasticity (SRP) is a robust and lasting modification of primary
visual cortex (V1) that occurs in response to exposure to novel visual stimuli. It is readily …

Fear learning and memory rely on dynamic interactions between the excitatory and
inhibitory neuronal populations that make up the prefrontal cortical, amygdala, and …

Dravet syndrome (DS) is a severe neurodevelopmental disorder caused by loss-of-function
variants in SCN1A, which encodes the voltage-gated sodium channel subunit Nav1. 1. We …