Oxidative cell death in cancer: mechanisms and therapeutic opportunities

X An, W Yu, J Liu, D Tang, L Yang, X Chen - Cell Death & Disease, 2024 - nature.com
Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated
as natural byproducts during cellular processes, including metabolism. Under normal …

Interactions of nanoparticles and biosystems: microenvironment of nanoparticles and biomolecules in nanomedicine

C Auría-Soro, T Nesma, P Juanes-Velasco… - Nanomaterials, 2019 - mdpi.com
Nanotechnology is a multidisciplinary science covering matters involving the nanoscale
level that is being developed for a great variety of applications. Nanomedicine is one of …

The gold complex auranofin: new perspectives for cancer therapy

FH Abdalbari, CM Telleria - Discover Oncology, 2021 - Springer
Advanced stages of cancer are highly associated with short overall survival in patients due
to the lack of long-term treatment options following the standard form of care. New options …

Gold (I/III)-phosphine complexes as potent antiproliferative agents

JH Kim, E Reeder, S Parkin, SG Awuah - Scientific reports, 2019 - nature.com
The reaction of gold reagents [HAuCl4• 3H2O],[AuCl (tht)], or cyclometalated gold (III)
precursor,[C^ NAuCl2] with chiral ((R, R)-(-)-2, 3-bis (t-butylmethylphosphino) quinoxaline) …

[HTML][HTML] A review on metal complexes and its anti-cancer activities: Recent updates from in vivo studies

S Adhikari, P Nath, A Das, A Datta, N Baildya… - Biomedicine & …, 2024 - Elsevier
Research into cancer therapeutics has uncovered various potential medications based on
metal-containing scaffolds after the discovery and clinical applications of cisplatin as an anti …

[HTML][HTML] Auranofin: Past to Present, and repurposing

M Yamashita - International Immunopharmacology, 2021 - Elsevier
Auranofin (AF), a gold compound, has been used to treat rheumatoid arthritis (RA) for more
than 40 years; however, its mechanism of action remains unknown. We revealed that AF …

The role of the thioredoxin detoxification system in cancer progression and resistance

M Jovanović, A Podolski-Renić, M Krasavin… - Frontiers in Molecular …, 2022 - frontiersin.org
The intracellular redox homeostasis is a dynamic balancing system between the levels of
free radical species and antioxidant enzymes and small molecules at the core of cellular …

Auranofin induces lethality driven by reactive oxygen species in high-grade serous ovarian cancer cells

FH Abdalbari, E Martinez-Jaramillo, BN Forgie, E Tran… - Cancers, 2023 - mdpi.com
Simple Summary High-grade serous ovarian cancer (HGSOC) is the most prevalent type of
ovarian cancer, accounting for 70% of ovarian cancer deaths. This is primarily due to the …

[HTML][HTML] Redox proteome analysis of auranofin exposed ovarian cancer cells (A2780)

G Chiappetta, T Gamberi, F Faienza, X Limaj, S Rizza… - Redox Biology, 2022 - Elsevier
The effects of Auranofin (AF) on protein expression and protein oxidation in A2780 cancer
cells were investigated through a strategy based on simultaneous expression proteomics …

Reaction Behavior of [1,3-Diethyl-4,5-diphenyl-1H-imidazol-2-ylidene] Containing Gold(I/III) Complexes against Ingredients of the Cell Culture Medium and the …

P Kapitza, A Scherfler, S Salcher… - Journal of Medicinal …, 2023 - ACS Publications
The reactivities of halido [1, 3-diethyl-4, 5-diphenyl-1 H-imidazol-2-ylidene] gold (I)(chlorido
(5), bromido (6), iodido (7)), bis [1, 3-diethyl-4, 5-diphenyl-1 H-imidazol-2-ylidene] gold (I)(8) …