HIV-exposed uninfected children: a growing population with a vulnerable immune system?

L Afran, M Garcia Knight, E Nduati… - Clinical & …, 2014 - academic.oup.com
Through the successful implementation of policies to prevent mother-to-child-transmission
(PMTCT) of HIV-1 infection, children born to HIV-1-infected mothers are now much less likely …

The immune system of HIV-exposed uninfected infants

B Abu-Raya, TR Kollmann, A Marchant… - Frontiers in …, 2016 - frontiersin.org
Infants born to human immunodeficiency virus (HIV) infected women are HIV-exposed but
the majority remains uninfected [ie, HIV-exposed uninfected (HEU)]. HEU infants suffer …

Immunology of pediatric HIV infection

NH Tobin, GM Aldrovandi - Immunological reviews, 2013 - Wiley Online Library
Most infants born to human immunodeficiency virus (HIV)‐infected women escape HIV
infection. Infants evade infection despite an immature immune system and, in the case of …

In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants

EB Kidzeru, AC Hesseling, JAS Passmore, L Myer… - Aids, 2014 - journals.lww.com
Objective: In sub-Saharan Africa, HIV-exposed uninfected (HEU) infants have higher
morbidity and mortality than HIV-unexposed infants. To evaluate whether immune …

Effect of HIV-1 exposure and antiretroviral treatment strategies in HIV-infected children on immunogenicity of vaccines during infancy

OE Simani, A Izu, A Violari, MF Cotton, N Van Niekerk… - Aids, 2014 - journals.lww.com
Methods: HIV-uninfected infants born to HIV-infected (HEU) or HIV-uninfected (HUU)
mothers were enrolled in parallel with HIV-infected children with CD4+≥ 25%, who were …

Impaired humoral response to vaccines among HIV-exposed uninfected infants

BM Abramczuk, TN Mazzola, YMF Moreno… - Clinical and Vaccine …, 2011 - Am Soc Microbiol
Little is known about the vaccine protective response for infants born from HIV-infected
mothers. We evaluated the antibody response to hepatitis B, tetanus, and diphtheria vaccine …

Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life

BA Reikie, S Naidoo, CE Ruck… - Clinical and vaccine …, 2013 - Am Soc Microbiol
ABSTRACT HIV-exposed but uninfected (HEU) infants born to HIV-infected mothers from
areas in the world with a high burden of infectious disease suffer higher infectious morbidity …

Impaired bacillus Calmette–Guérin cellular immune response in HIV-exposed, uninfected infants

TN Mazzola, MTN da Silva, BM Abramczuk… - Aids, 2011 - journals.lww.com
Objective: To evaluate cell-mediated immune response to Bacillus Calmette–Guérin (BCG)
vaccination in uninfected, HIV-1-exposed infants, comparing it with unexposed children …

Impact of maternal HIV-1 viremia on lymphocyte subsets among HIV-exposed uninfected infants: protective mechanism or immunodeficiency

F Kakkar, V Lamarre, T Ducruet, M Boucher… - BMC infectious …, 2014 - Springer
Background Reports of increased morbidity and mortality from infectious diseases among
HIV Exposed Uninfected (HEU) infants have raised concern about a possible underlying …

Impact of HIV exposure on health outcomes in HIV-negative infants born to HIV-positive mothers in Sub-Saharan Africa

C Moraleda, N de Deus, C Serna-Bolea… - JAIDS Journal of …, 2014 - journals.lww.com
Background: Up to 30% of infants may be HIV-exposed noninfected (ENI) in countries with
high HIV prevalence, but the impact of maternal HIV on the child's health remains unclear …