Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Macrophages are versatile and heterogeneous innate immune cells undertaking central
functions in balancing immune responses and tissue repair to maintain homeostasis. This …

Cancer progression is primarily caused by interactions between transformed cells and the
components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) …

Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and
metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby …

Background Conventional immunohistochemistry technologies were limited by the inability
to simultaneously detect multiple markers and the lack of identifying spatial relationships …

In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) are the most
abundant immune cells, which act as a key regulator in tumorigenesis and progression …

Elimination of cancer stem cells (CSCs) and reinvigoration of antitumor immunity remain
unmet challenges for cancer therapy. Tumor-associated macrophages (TAMs) constitute the …

In recent years head-to-tail monoterpene geraniol has been widely explored as a potential
anticancer agent. Natural analogs like alcohol nerol, aldehydes geranial, and neral have …

Abstract Cell-based immunotherapies (CBIs), notably exemplified by chimeric antigen
receptor (CAR)-engineered T (CAR-T) cell therapy, have emerged as groundbreaking …

Increasing evidence indicate that cancer stem cells (CSCs) are the key driver of tumor
initiation and recurrence. The cellular and soluble components of the tumor …