Electroencephalographic (EEG) biomarkers in genetic neurodevelopmental disorders

K Goodspeed, D Armstrong, A Dolce… - Journal of child …, 2023 - journals.sagepub.com
Collectively, neurodevelopmental disorders are highly prevalent, but more than a third of
neurodevelopmental disorders have an identifiable genetic etiology, each of which is …

Sex-Related Changes in the Clinical, Genetic, Electrophysiological, Connectivity, and Molecular Presentations of ASD: A Comparison between Human and Animal …

A Ornoy, D Gorobets, L Weinstein-Fudim… - International Journal of …, 2023 - mdpi.com
The etiology of autism spectrum disorder (ASD) is genetic, environmental, and epigenetic. In
addition to sex differences in the prevalence of ASD, which is 3–4 times more common in …

Results of a phase Ib study of SB-121, an investigational probiotic formulation, a randomized controlled trial in participants with autism spectrum disorder

LM Schmitt, EG Smith, EV Pedapati, PS Horn, M Will… - Scientific Reports, 2023 - nature.com
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized
by core impairments in social communication as well as restricted, repetitive patterns of …

Neocortical localization and thalamocortical modulation of neuronal hyperexcitability contribute to Fragile X Syndrome

EV Pedapati, LM Schmitt, LE Ethridge… - Communications …, 2022 - nature.com
Abstract Fragile X Syndrome (FXS) is a monogenetic form of intellectual disability and
autism in which well-established knockout (KO) animal models point to neuronal …

FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT1A, 5-HT1B, and 5-HT1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 …

TS Saraf, RP McGlynn, OM Bhatavdekar… - ACS chemical …, 2022 - ACS Publications
There are no approved medicines for fragile X syndrome (FXS), a monogenic,
neurodevelopmental disorder. Electroencephalogram (EEG) studies show alterations in …

EEG microstates as markers for cognitive impairments in Fragile X Syndrome

Y Takarae, A Zanesco, CA Erickson, EV Pedapati - Brain Topography, 2024 - Springer
Fragile X syndrome (FXS) is one of the most common inherited causes of intellectual
disabilities. While there is currently no cure for FXS, EEG is considered an important method …

EEG signal complexity is reduced during resting-state in fragile X syndrome

M Proteau-Lemieux, IS Knoth, K Agbogba… - Frontiers in …, 2021 - frontiersin.org
Introduction: Fragile X syndrome (FXS) is a genetic disorder caused by a mutation of the
fragile X mental retardation 1 gene (FMR1). FXS is associated with neurophysiological …

Hemispheric utilization of alpha oscillatory dynamics as a unique biomarker of neural compensation in females with fragile X syndrome

JE Norris, LA DeStefano, LM Schmitt… - ACS chemical …, 2022 - ACS Publications
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a trinucleotide
expansion on the FMR1 gene and characterized by intellectual disability, sensory …

[HTML][HTML] Reliability of resting-state electrophysiology in fragile X syndrome

R Liu, EV Pedapati, LM Schmitt, RC Shaffer… - Biomarkers in …, 2023 - Elsevier
Abstract Objective Fragile X Syndrome (FXS) is the leading monogenic cause of intellectual
disability and autism spectrum disorder. Currently, there are no established biomarkers for …

Baclofen-associated neurophysiologic target engagement across species in fragile X syndrome

CR Jonak, EV Pedapati, LM Schmitt, SA Assad… - Journal of …, 2022 - Springer
Abstract Background Fragile X syndrome (FXS) is the most common inherited form of
neurodevelopmental disability. It is often characterized, especially in males, by intellectual …