Amyloid-forming properties of human apolipoproteins: sequence analyses and structural insights

M Das, O Gursky - Lipids in Protein Misfolding, 2015 - Springer
Apolipoproteins are protein constituents of lipoproteins that transport cholesterol and fat in
circulation and are central to cardiovascular health and disease. Soluble apolipoproteins …

Aggregation susceptibility of low-density lipoproteins—a novel modifiable biomarker of cardiovascular risk

K Öörni, PT Kovanen - Journal of clinical medicine, 2021 - mdpi.com
Circulating low-density lipoprotein (LDL) particles enter the arterial intima where they bind to
the extracellular matrix and become modified by lipases, proteases, and oxidizing enzymes …

Selective regulation of macrophage lipid metabolism via nanomaterials' surface chemistry

J Wu, X Bai, L Yan, D Baimanov, Y Cong… - Nature …, 2024 - nature.com
Understanding the interface between nanomaterials and lipoproteins is crucial for gaining
insights into their impact on lipoprotein structure and lipid metabolism. Here, we use …

Electronegative LDL promotes inflammation and triglyceride accumulation in macrophages

N Puig, L Montolio, P Camps-Renom, L Navarra… - Cells, 2020 - mdpi.com
Electronegative low-density lipoprotein (LDL)(LDL (−)), a modified LDL that is present in
blood and exerts atherogenic effects on endothelial cells and monocytes. This study aimed …

Aggregation and fusion of low-density lipoproteins in vivo and in vitro

M Lu, O Gursky - Biomolecular concepts, 2013 - degruyter.com
Low-density lipoproteins (LDLs, also known as 'bad cholesterol') are the major carriers of
circulating cholesterol and the main causative risk factor of atherosclerosis. Plasma LDLs …

Electronegative LDL: a circulating modified LDL with a role in inflammation

M Estruch, JL Sánchez-Quesada… - Mediators of …, 2013 - Wiley Online Library
Electronegative low density lipoprotein (LDL (−)) is a minor modified fraction of LDL found in
blood. It comprises a heterogeneous population of LDL particles modified by various …

Neutrophils as a novel target of modified low-density lipoproteins and an accelerator of cardiovascular diseases

T Obama, H Itabe - International journal of molecular sciences, 2020 - mdpi.com
Neutrophil extracellular traps (NETs) significantly contribute to various pathophysiological
conditions, including cardiovascular diseases. NET formation in the vasculature exhibits …

Electronegative LDL induces priming and inflammasome activation leading to IL-1β release in human monocytes and macrophages

M Estruch, K Rajamäki, JL Sanchez-Quesada… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Abstract Background: Electronegative LDL (LDL (−)), a modified LDL fraction found in blood,
induces the release of inflammatory mediators in endothelial cells and leukocytes. However …

Electronegative low-density lipoprotein. A link between apolipoprotein B misfolding, lipoprotein aggregation and proteoglycan binding

JL Sánchez-Quesada, S Villegas… - Current opinion in …, 2012 - journals.lww.com
LDL (−) could play a relevant role in atherogenesis by acting as a priming factor that
stimulates lipoprotein aggregation. This process, which appears to be mediated by a PLC …

Thirty-five-year history of desialylated lipoproteins discovered by Vladimir Tertov

V Glanz, EE Bezsonov, V Soldatov, AN Orekhov - Biomedicines, 2022 - mdpi.com
Atherosclerosis is one of the leading causes of death in developed and developing
countries. The atherogenicity phenomenon cannot be separated from the role of modified …