The innovative development of azapeptide analogues of growth hormone releasing peptide-
6 (GHRP-6) has produced selective modulators of the cluster of differentiation 36 receptor …

After the first synthesis reported in 1994, azabicycloalkane amino acids have raised
increasing interest, becoming one of the most important classes of constrained dipeptide …

Interleukin-1β (IL-1β) binds to the IL-1 receptor (IL-1R) and is a key cytokine mediator of
inflammasome activation. IL-1β signaling leads to parturition in preterm birth (PTB) and …

Solid-phase chemistry for the synthesis and Diels–Alder reaction of Fmoc-protected
azopeptides has been developed and used to construct aza-pipecolyl (azaPip) peptides …

α-N-(Fmoc) Amino-γ-lactam dipeptides with a variety of β-substituents were synthesized
stereoselectively with minimal β-elimination by routes employing, respectively, Mitsunobu …

Azacyclo-and azabicycloalkanone peptidomimetics were synthesized regio-and
diastereoselectively by iodoacetoxylation and transannular amidation reactions on …

As a key cytokine mediator of inflammation, interleukin-1β (IL-1β) binds to the IL-1 receptor
(IL-1R) and activates various downstream signaling mediators, including NF-κB, which is …

Herein we report the preparation of C4‐functionalized proline‐derived azabicycloalkane
(Aba) amino acids by exploiting a direct ring closing enyne metathesis reaction of readily …

The almiramide N-methylated lipopeptides exhibit promising activity against trypanosomatid
parasites. A structure–activity relationship study has been performed to examine the …

N-Aminoimidazolidin-2-one (Aid)-containing peptides with a constrained backbone present
a novel class of peptidomimetics for drug discovery. The introduction of Aid residues into …