Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula

L Zhao, H Zhang, N Li, J Chen, H Xu, Y Wang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Network pharmacology is a new discipline based on
systems biology theory, biological system network analysis, and multi-target drug molecule …

Matrix metalloproteinase 2 as a pharmacological target in heart failure

PR Gonçalves, LD Nascimento, RF Gerlach… - Pharmaceuticals, 2022 - mdpi.com
Heart failure (HF) is an acute or chronic clinical syndrome that results in a decrease in
cardiac output and an increase in intracardiac pressure at rest or upon exertion. The …

Genome-wide analysis of left ventricular image-derived phenotypes identifies fourteen loci associated with cardiac morphogenesis and heart failure development

N Aung, JD Vargas, C Yang, CP Cabrera, HR Warren… - Circulation, 2019 - Am Heart Assoc
Background: The genetic basis of left ventricular (LV) image-derived phenotypes, which play
a vital role in the diagnosis, management, and risk stratification of cardiovascular diseases …

[HTML][HTML] Mitochondrial quality control in diabetic cardiomyopathy: from molecular mechanisms to therapeutic strategies

C Cai, F Wu, J He, Y Zhang, N Shi, X Peng… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
In diabetic cardiomyopathy (DCM), a major diabetic complication, the myocardium is
structurally and functionally altered without evidence of coronary artery disease …

Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway

H Li, M Zhang, Y Wang, K Gong, T Yan, D Wang… - Food & function, 2022 - pubs.rsc.org
Heart failure (HF) is a clinical syndrome characterized by typical symptoms that usually
occur at the end stage of various heart diseases and lead to death. Daidzein (DAI), an …

Long-term outcomes of left bundle branch area pacing versus biventricular pacing in patients with heart failure and complete left bundle branch block

J Hua, Y Chen, J Yu, Q Xiong, Z Xia, Z Xia, Q Huang… - Heart and Vessels, 2022 - Springer
Left bundle branch area pacing (LBBAP) has developed in an effort to improve cardiac
resynchronization therapy (CRT). We aimed to compare the long-term clinical outcomes …

O-GlcNAcylation, a sweet link to the pathology of diseases

H Nie, W Yi - Journal of Zhejiang University-SCIENCE B, 2019 - Springer
Abstract O-linked N-acetylglucosamine (O-GlcNAc) is a dynamic post-translational
modification occurring on myriad proteins in the cell nucleus, cytoplasm, and mitochondria …

ChatGPT and patients with heart failure

F Dimitriadis, S Alkagiet, L Tsigkriki, P Kleitsioti… - …, 2024 - journals.sagepub.com
ChatGPT (Generative Pre-trained Transformer) is a large-scale language processing model,
with possibilities for professional patient support in a patient-friendly way. The aim of the …

Characterizing shared and distinct symptom clusters in common chronic conditions through natural language processing of nursing notes

TA Koleck, M Topaz, NP Tatonetti… - Research in nursing …, 2021 - Wiley Online Library
Data‐driven characterization of symptom clusters in chronic conditions is essential for
shared cluster detection and physiological mechanism discovery. This study aims to …

Cinnamaldehyde activates AMPK/PGC-1α pathway via targeting GRK2 to ameliorate heart failure

Z Xu, M Li, D Lyu, H Xiao, S Li, Z Li, M Li, J Xiao… - Phytomedicine, 2024 - Elsevier
Background According to recent research, treating heart failure (HF) by inhibiting G protein-
coupled receptor kinase 2 (GRK2) to improve myocardial energy metabolism has been …