[HTML][HTML] Innate immunity drives pathogenesis of rheumatoid arthritis

MI Edilova, A Akram, AA Abdul-Sater - Biomedical Journal, 2021 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disease affecting∼ 1% of the general
population. This disease is characterized by persistent articular inflammation and joint …

MicroRNAs in rheumatoid arthritis: From pathogenesis to clinical impact

G Evangelatos, GE Fragoulis, V Koulouri… - Autoimmunity reviews, 2019 - Elsevier
Over the last decade, many epigenetic mechanisms that contribute in the pathogenesis of
autoimmune disorders have been revealed. MicroRNAs (miRNAs) are small, non-coding …

Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis

R Kolhe, M Hunter, S Liu, RN Jadeja, C Pundkar… - Scientific reports, 2017 - nature.com
The pathogenesis of osteoarthritis (OA) is poorly understood, and therapeutic approaches
are limited to preventing progression of the disease. Recent studies have shown that …

Exosomes rewire the cartilage microenvironment in osteoarthritis: from intercellular communication to therapeutic strategies

Y Wu, J Li, Y Zeng, W Pu, X Mu, K Sun… - International journal of …, 2022 - nature.com
Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by cartilage loss
and accounts for a major source of pain and disability worldwide. However, effective …

Environmental exposures and autoimmune diseases: contribution of gut microbiome

MF Khan, H Wang - Frontiers in immunology, 2020 - frontiersin.org
Environmental agents have been gaining more attention in recent years for their role in the
pathogenesis of autoimmune diseases (ADs). Increasing evidence has linked environmental …

MicroRNAs: new regulators of Toll‐like receptor signalling pathways

X He, Z Jing, G Cheng - BioMed research international, 2014 - Wiley Online Library
Toll‐like receptors (TLRs), a critical family of pattern recognition receptors (PRRs), are
responsible for the innate immune responses via signalling pathways to provide effective …

Deregulation and therapeutic potential of microRNAs in arthritic diseases

R Vicente, D Noël, YM Pers, F Apparailly… - Nature Reviews …, 2016 - nature.com
Epigenetic abnormalities are part of the pathogenetic alterations involved in the
development of rheumatic disorders. In this context, the main musculoskeletal cell lineages …

[HTML][HTML] The role of non-coding RNAs (miRNA and lncRNA) in the clinical management of rheumatoid arthritis

J Yang, Z Li, L Wang, X Yun, Y Zeng, JPL Ng… - Pharmacological …, 2022 - Elsevier
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder which is associated
with the dysregulation of autoimmune response. In recent years, early diagnosis, aggressive …

Neuro-protective roles of long non-coding RNA MALAT1 in Alzheimer's disease with the involvement of the microRNA-30b/CNR1 network and the following PI3K/AKT …

L Li, Y Xu, M Zhao, Z Gao - Experimental and molecular pathology, 2020 - Elsevier
Long non-coding RNAs (lncRNAs) have been increasingly found to fulfill key functions in
neurodegenerative diseases. This study aimed to probe the function of lncRNA MALAT1 in …

Recent advances in nano-targeting drug delivery systems for rheumatoid arthritis treatment

H Li, R Gou, J Liao, Y Wang, R Qu, Q Tang… - Acta Materia …, 2023 - scienceopen.com
Rheumatoid arthritis is a systemic inflammatory disease that can lead to articular cartilage
destruction and periarticular bone erosion, thus ultimately compromising joint integrity and …