Pericytes are vascular mural cells embedded in the basement membrane of blood
microvessels. They extend their processes along capillaries, pre-capillary arterioles and …

Central nervous system (CNS) barriers predominantly mediate the immune-privileged status
of the brain, and are also important regulators of neuroimmune communication. It is …

Increases in brain blood flow, evoked by neuronal activity, power neural computation and
form the basis of BOLD (blood-oxygen-level-dependent) functional imaging. Whether blood …

The consequences of cerebrovascular disease are among the leading health issues
worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the …

Brain edema is a severe stroke complication that is associated with prolonged
hospitalization and poor outcomes. Swollen tissues in the brain compromise cerebral …

Introduction Blood–brain barrier (BBB) dysfunction may occur at the onset of Alzheimer's
disease (AD). Pericytes are a vital part of the neurovascular unit and the BBB, acting as …

Pericytes, attached to the surface of capillaries, play an important role in regulating local
blood flow. Using optogenetic tools and genetically encoded reporters in conjunction with …

Many central nervous system diseases currently lack effective treatment and are often
associated with defects in microvascular function, including a failure to match the energy …

Because regional blood flow increases in association with the increased metabolic demand
generated by localised increases in neural activity, functional imaging researchers often …

The blood–brain barrier (BBB) is the specialized system of brain microvascular endothelial
cells (BMVEC) that shields the brain from toxic substances in the blood, supplies brain …