Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
P Mikulska, M Malinowska, M Ignacyk, P Szustowski… - Pharmaceutics, 2023 - mdpi.com
In recent years, there has been a significant surge in reports on the health-promoting
benefits of winter cherry (Withania somnifera), also known as Ashwagandha. Its current …
benefits of winter cherry (Withania somnifera), also known as Ashwagandha. Its current …
Genetic origins, regulators, and biomarkers of cellular senescence
G Torres, IA Salladay-Perez, A Dhingra… - Trends in Genetics, 2024 - cell.com
This review comprehensively examines the molecular biology and genetic origins of cellular
senescence. We focus on various cellular stressors and pathways leading to senescence …
senescence. We focus on various cellular stressors and pathways leading to senescence …
Molecular mechanism of anti-SARS-CoV2 activity of Ashwagandha-derived withanolides
COVID-19 caused by SARS-CoV-2 corona virus has become a global pandemic. In the
absence of drugs and vaccine, and premises of time, efforts and cost required for their …
absence of drugs and vaccine, and premises of time, efforts and cost required for their …
Why is mortalin a potential therapeutic target for cancer?
Cancer is one of the leading causes of death worldwide, accounting for nearly 10 million
deaths in 2020. Therefore, cancer therapy is a priority research field to explore the biology of …
deaths in 2020. Therefore, cancer therapy is a priority research field to explore the biology of …
[HTML][HTML] Covalent binding of withanolides to cysteines of protein targets
C Bailly - Biochemical Pharmacology, 2024 - Elsevier
Withanolides represent an important category of natural products with a steroidal lactone
core. Many of them contain an α, β-unsaturated carbonyl moiety with a high reactivity toward …
core. Many of them contain an α, β-unsaturated carbonyl moiety with a high reactivity toward …
Combination of withaferin-A and CAPE provides superior anticancer potency: Bioinformatics and experimental evidence to their molecular targets and mechanism of …
We have earlier reported anticancer activity in Withaferin A (Wi-A), a withanolide derived
from Ashwagandha (Withania somnifera) and caffeic acid phenethyl ester (CAPE), an active …
from Ashwagandha (Withania somnifera) and caffeic acid phenethyl ester (CAPE), an active …
[HTML][HTML] Molecular Insights into the Anticancer Activity of Withaferin-A: The Inhibition of Survivin Signaling
Simple Summary The inactivation of apoptotic signaling by inhibitors of apoptosis proteins
(IAPs) is one of the important hallmarks of cancer cells. Survivin, a 16.5 kDa member of the …
(IAPs) is one of the important hallmarks of cancer cells. Survivin, a 16.5 kDa member of the …
COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays
SARS-CoV-2 outbreak in China in December 2019 and its spread as worldwide pandemic
has been a major global health crisis. Extremely high infection and mortality rate has …
has been a major global health crisis. Extremely high infection and mortality rate has …
Computational insights into the potential of Withaferin-A, withanone and caffeic acid phenethyl ester for treatment of aberrant-EGFR driven lung cancers
The anticancer activities of Withaferin-A (Wi-A) and Withanone (Wi-N) from Ashwagandha
and Caffeic Acid Phenethyl Ester (CAPE) from honeybee propolis have been well …
and Caffeic Acid Phenethyl Ester (CAPE) from honeybee propolis have been well …
Computational identification of BCR-ABL oncogenic signaling as a candidate target of Withaferin A and withanone
Withaferin-A (Wi-A), a secondary metabolite extracted from Ashwagandha (Withania
somnifera), has been shown to possess anticancer activity. However, the molecular …
somnifera), has been shown to possess anticancer activity. However, the molecular …