Eukaryotic translation elongation factors 1 alpha, eEF1A1 and eEF1A2, are not only
translation factors but also pleiotropic proteins that are highly expressed in human tumors …

The prokaryotic translation elongation factors were identified as essential cofactors for RNA-
dependent RNA polymerase activity of the bacteriophage Qβ more than 40 years ago. A …

During protein synthesis, nonsense mutations, resulting in premature stop codons (PSCs),
produce truncated, inactive protein products. Such defective gene products give rise to many …

Genetic diseases are often caused by nonsense mutations, but only one TRID (translation
readthrough inducing drug), ataluren, has been approved for clinical use. Ataluren inhibits …

In tumourigenesis, oncogenes or dysregulated tumour suppressor genes alter the canonical
translation machinery leading to a reprogramming of the translatome that, in turn, promotes …

Background miR-663 is associated with many important biologic processes, such as the
evolution, development, viral infection, inflammatory response, and carcinogenesis among …

Lysine methylation is abundant on histone proteins, representing a dynamic regulator of
chromatin state and gene activity, but is also frequent on many non-histone proteins …

The dysregulation of long non-coding RNAs (lncRNAs) are involved in regulating tumor
progression in multiple manner. However, little is known about whether lncRNA is involved …

Synaptic plasticity involves structural modifications in dendritic spines that are modulated by
local protein synthesis and actin remodeling. Here, we investigated the molecular …

The multi‐subunit eEF1 complex plays a crucial role in de novo protein synthesis. The
central functional component of the complex is eEF1A, which occurs as two independently …