Urease is a metalloenzyme including two Ni2+ ions, found in some plants, bacteria, fungi,
microorganisms, invertebrate animals, and animal tissues. Urease acts as a significant …

A series of 32 thiourea-based urease inhibitors were synthesized and evaluated against
native bacterial enzyme and whole cells of Sporosarcina pasteurii and Proteus mirabilis …

Microbial Ni2+ homeostasis underpins the virulence of several clinical pathogens. Ni2+ is
an essential cofactor in urease and [NiFe]-hydrogenases involved in colonization and …

Background and objectives Lifestyle-related diseases (LSDs) impose a substantial
economic burden on patients and health care services. LSDs are chronic in nature and can …

Designing and developing small organic molecules for use as urease inhibitors is
challenging due to the need for ecosystem sustainability and the requirement to prevent …

Urease is a nickel-containing enzyme encoded by several microorganisms and plants since
its physiological role, involving the conversion of urea into ammonia, is crucial for their …

Urease is a metalloenzyme that catalyzes the hydrolysis of urea, and its modulation has an
important role in both the agricultural and medical industry. Even though numerous …

Antimicrobial resistance is a global health threat that requires innovative strategies against
drug-resistant bacteria. Our study focuses on enoyl-acyl carrier protein reductases (ENRs) …

Recent progress in “Green” Nanotechnology is trying to fight against many diseases, a
special interest being given to silver-based nanoparticles biogenerated from plants. In this …

The identification of novel anti-infective agents of synthetic and natural origin represents one
of the main aims of contemporary drug discovery. In the current work, four different varieties …