The β-carboline Harmine improves the therapeutic benefit of anti-PD1 in melanoma by increasing the MHC-I-dependent antigen presentation
MZ Noman, IA Bocci, M Karam, KV Moer… - Frontiers in …, 2022 - frontiersin.org
Harmine is a dual-specificity tyrosine-regulated kinase 1A (DYRK1A) inhibitor that displays a
number of biological and pharmacological properties. Also referred to as ACB1801 …
number of biological and pharmacological properties. Also referred to as ACB1801 …
MHC-1 Mediated Antigen Presentation Machinery as a Key of Tumor Cells Immune Escape Control
CB Auclair, A Ives - Journal of Immunological …, 2021 - immunologyresearchjournal.com
Background Immune escape is one of the key mechanisms mediating cancer progression
and metastatic invasion. This creates significant obstacles to successful cancer treatment …
and metastatic invasion. This creates significant obstacles to successful cancer treatment …