Postoperative atrial fibrillation (POAF) complicates 20–40% of cardiac surgical procedures
and 10–20% of non-cardiac thoracic operations. Typical features include onset at 2–4 days …

HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Rationale: Postoperative atrial fibrillation (POAF) is a common and troublesome
complication of cardiac surgery. POAF is generally believed to occur when postoperative …

5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in both the central nervous
system and peripheral structures, acting also as a hormone in platelets. Although its …

Serotonin, 5-hydroxytryptamine (5-HT), is one of the class of monoamine neurontransmitters,
all of which have a chemical template comprised of a basic amino group separated from an …

Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The
effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as …

Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …

Hydroxytryptamine4 (5‐HT4) receptors are an interesting target for the management of
patients in need of gastrointestinal (GI) promotility treatment. They have proven therapeutic …

Aims Atrial fibrillation (AF) is a commonly occurring arrhythmia after cardiac surgery
(postoperative AF, poAF) and is associated with poorer outcomes. Considering that reduced …

Atrial fibrillation (AF) is the most prevalent sustained arrhythmia. As the most important risk
factor for embolic stroke, AF is associated with a high morbidity and mortality. Despite …