Cell clusters are indicative of stem cell activity in the degenerate intervertebral disc: can their properties be manipulated to improve intrinsic repair of the disc?
The aim of this study was to examine the complexity of the stem cell populations in the
intervertebral disc (IVD) and understand their role in disc degeneration, with a view of …
intervertebral disc (IVD) and understand their role in disc degeneration, with a view of …
The mouse fetal‐placental arterial connection: A paradigm involving the primitive streak and visceral endoderm with implications for human development
KM Downs, AM Rodriguez - Wiley Interdisciplinary Reviews …, 2020 - Wiley Online Library
In Placentalia, the fetus depends upon an organized vascular connection with its mother for
survival and development. Yet, this connection was, until recently, obscure. Here, we …
survival and development. Yet, this connection was, until recently, obscure. Here, we …
The CS sulfation motifs 4C3, 7D4, 3B3 [−]; and perlecan identify stem cell populations and their niches, activated progenitor cells and transitional areas of tissue …
AJ Hayes, CE Hughes, SM Smith… - Stem Cells and …, 2016 - liebertpub.com
We compared the immunohistochemical distribution of (1) the novel chondroitin sulfate (CS)
sulfation motifs 7D4, 4C3, and 3B3 [−],(2) native heparan sulfate (HS) and Δ-HS “stubs” …
sulfation motifs 7D4, 4C3, and 3B3 [−],(2) native heparan sulfate (HS) and Δ-HS “stubs” …
[HTML][HTML] Visceral endoderm and the primitive streak interact to build the fetal-placental interface of the mouse gastrula
AM Rodriguez, KM Downs - Developmental biology, 2017 - Elsevier
Hypoblast/visceral endoderm assists in amniote nutrition, axial positioning and formation of
the gut. Here, we provide evidence, currently limited to humans and non-human primates …
the gut. Here, we provide evidence, currently limited to humans and non-human primates …
Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics?
D Gerovska, MJ Arauzo-Bravo - MHR: Basic science of …, 2016 - academic.oup.com
STUDY HYPOTHESIS Does primordial germ cell (PGC) activation start before mouse
embryo implantation, and does the possible regulation of the DNA (cytosine-5-) …
embryo implantation, and does the possible regulation of the DNA (cytosine-5-) …
[HTML][HTML] STELLA-positive subregions of the primitive streak contribute to posterior tissues of the mouse gastrula
MM Mikedis, KM Downs - Developmental biology, 2012 - Elsevier
The developmental relationship between the posterior embryonic and extraembryonic
regions of the mammalian gastrula is poorly understood. Although many different cell types …
regions of the mammalian gastrula is poorly understood. Although many different cell types …
[PDF][PDF] Perlecan delineates stem cell niches in human foetal hip, knee and elbow cartilage rudiments and has potential roles in the regulation of stem cell differentiation
This study immunolocalized perlecan, Type I and II collagen and aggrecan in human foetal
joint rudiment cartilages of the hip, knee and elbow. Blood vessels in the stromal tissues …
joint rudiment cartilages of the hip, knee and elbow. Blood vessels in the stromal tissues …
Widespread but tissue-specific patterns of interferon-induced transmembrane protein 3 (IFITM3, FRAGILIS, MIL-1) in the mouse gastrula
MM Mikedis, KM Downs - Gene Expression Patterns, 2013 - Elsevier
Interferon-induced transmembrane protein 3 (IFITM3; FRAGILIS; MIL-1) is part of a larger
family of important small interferon-induced transmembrane genes and proteins involved in …
family of important small interferon-induced transmembrane genes and proteins involved in …
Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc
Heparan sulfate (HS) regulates diverse cell signalling events in intervertebral disc
development and homeostasis. The aim of the present study was to investigate the effect of …
development and homeostasis. The aim of the present study was to investigate the effect of …
PRDM1/BLIMP1 is widely distributed to the nascent fetal–placental interface in the mouse gastrula
MM Mikedis, KM Downs - Developmental Dynamics, 2017 - Wiley Online Library
Background: PRDM1 is a transcriptional repressor that contributes to primordial germ cell
(PGC) development. During early gastrulation, epiblast‐derived PRDM1 is thought to be …
(PGC) development. During early gastrulation, epiblast‐derived PRDM1 is thought to be …