[HTML][HTML] Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases

C Gubert, G Kong, T Renoir, AJ Hannan - Neurobiology of disease, 2020 - Elsevier
The last decade has witnessed an exponentially growing interest in gut microbiota and the
gut-brain axis in health and disease. Accumulating evidence from preclinical and clinical …

Depression in neurodegenerative diseases: Common mechanisms and current treatment options

CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience‐dependent …

AJ Hannan - Neuropathology and applied neurobiology, 2014 - Wiley Online Library
Environmental enrichment (EE) increases levels of novelty and complexity, inducing
enhanced sensory, cognitive and motor stimulation. In wild‐type rodents, EE has been found …

Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?

X Du, TY Pang - Frontiers in psychiatry, 2015 - frontiersin.org
There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Standardized environmental enrichment supports enhanced brain plasticity in healthy rats and prevents cognitive impairment in epileptic rats

RP Fares, A Belmeguenai, PE Sanchez, HY Kouchi… - PloS one, 2013 - journals.plos.org
Environmental enrichment of laboratory animals influences brain plasticity, stimulates
neurogenesis, increases neurotrophic factor expression, and protects against the effects of …

Enhancement of cognitive function in models of brain disease through environmental enrichment and physical activity

TYC Pang, AJ Hannan - Neuropharmacology, 2013 - Elsevier
This review will provide an overview of the non-drug based approaches that have been
demonstrated to enhance cognitive function of the compromised brain, primarily focussed on …

The relative benefits of environmental enrichment on learning and memory are greater when stressed: A meta-analysis of interactions in rodents

EL Macartney, M Lagisz, S Nakagawa - Neuroscience & Biobehavioral …, 2022 - Elsevier
Abstract Environmental enrichment (“EE”) is expected to alleviate the negative effects of
stress on cognitive performance. However, there are complexities associated with …

Environmental enrichment and the sensory brain: the role of enrichment in remediating brain injury

DS Alwis, R Rajan - Frontiers in systems neuroscience, 2014 - frontiersin.org
The brain's life-long capacity for experience-dependent plasticity allows adaptation to new
environments or to changes in the environment, and to changes in internal brain states such …

Systemic manifestation and contribution of peripheral tissues to Huntington's disease pathogenesis

CL Chuang, F Demontis - Ageing research reviews, 2021 - Elsevier
Huntington disease (HD) is an autosomal dominant neurodegenerative disease that is
caused by expansion of cytosine/adenosine/guanine repeats in the huntingtin (HTT) gene …

Environmental factors as modulators of neurodegeneration: Insights from gene–environment interactions in Huntington's disease

C Mo, AJ Hannan, T Renoir - Neuroscience & Biobehavioral Reviews, 2015 - Elsevier
Unlike many other neurodegenerative diseases with established gene–environment
interactions, Huntington's disease (HD) is viewed as a disorder governed by genetics. The …