BACKGROUND Chemotherapy-associated ovarian damage (CAOD) is one of the most
feared short-and long-term side effects of anticancer treatment in premenopausal women …

The ovary is one of the first organs to show overt signs of aging in the human body, and
ovarian aging is associated with a loss of gamete quality and quantity. The age-dependent …

The ovary ages earlier than most other tissues, yet the underlying mechanisms remain
elusive. Here a comprehensive analysis of transcriptomic landscapes in different organs in …

The ovary is indispensable for female reproduction, and its age-dependent functional
decline is the primary cause of infertility. However, the molecular basis of ovarian aging in …

Organismal aging involves functional declines in both somatic and reproductive tissues.
Multiple strategies have been discovered to extend lifespan across species. However, how …

Purpose We investigated the interactions between mural granulosa cells (MGCs) and
cumulus granulosa cells (CGCs) during ovulation after the LH surge. Methods We performed …

Limited understanding exists regarding how aging impacts the cellular and molecular
aspects of the human ovary. This study combines single-cell RNA sequencing and spatial …

This review explores the relationship between ovarian aging and senescent cell
accumulation, as well as the efficacy of senolytics to improve reproductive longevity …

In brief Recent reports suggest a relationship between ovarian inflammation and functional
declines, although it remains unresolved if ovarian inflammation is the cause or …

Reproductive aging in female mammals is characterized by ovarian senescence, leading to
a significant fertility decline. Lycium barbarum berry, or goji berry, is a food and medicine …