Mechanosensing describes the ability of a cell to sense mechanical cues of its
microenvironment, including not only all components of force, stress, and strain but also …

Cells actively interact with their microenvironment, constantly sensing and modulating
biochemical and biophysical signals. Blood comprises a variety of non-adherent cells that …

Hemostatic materials are of great importance in medicine. However, their successful
implementation is still challenging as it depends on two, often counteracting, attributes; …

A State of the Art lecture titled “Blood Clot Contraction: Mechanisms, Pathophysiology, and
Disease” was presented at the International Society on Thrombosis and Haemostasis (ISTH) …

Molecular forces generated by cell receptors are infrequent and transient, and hence difficult
to detect. Here we report an assay that leverages the CRISPR-associated protein 12a …

In the last decade, DNA-based tension sensors have made significant contributions to the
study of the importance of mechanical forces in many biological systems. Albeit successful …

Platelet aggregation at the site of vascular injury is essential in clotting. During this process,
platelets are bridged by soluble fibrinogen that binds surface integrin receptors. One mystery …

Cells transmit piconewton forces to receptors to mediate processes such as migration and
immune recognition. A major challenge in quantifying such forces is the sparsity of cell …

Platelets contract forcefully after their activation, contributing to the strength and stability of
platelet aggregates and fibrin clots during blood coagulation. Viscoelastic approaches can …

MYH9-related disease patients with mutations in the contractile protein nonmuscle myosin
heavy chain IIA display, among others, macrothrombocytopenia and a mild-to-moderate …