Numerous studies have shown that epigenetic age—an individual's degree of aging based
on patterns of DNA methylation—can be computed and is associated with an array of factors …

Purpose The fat mass-and obesity-associated (FTO) gene on chromosome 16q12. 2 shows
an intimate association with obesity and body mass index. Recently, research into the FTO …

Although mutation provides the fuel for phenotypic evolution, it also imposes a substantial
burden on fitness through the production of predominantly deleterious alleles, a matter of …

The pandemic caused by the spread of SARS-CoV-2 has led to considerable interest in its
evolutionary origin and genome structure. Here, we analyzed mutation patterns in 34 human …

Ageing, a leading cause of the decline/deficits in human learning, memory, and cognitive
abilities, is a major risk factor for age-associated neurodegenerative disorders such as …

An increasing number of epilepsies are being attributed to variants in genes with epigenetic
functions. The products of these genes include factors that regulate the structure and …

It is well known that the dinucleotide CpG is under-represented in the genomic DNA of many
vertebrates. This is commonly thought to be due to the methylation of cytosine residues in …

Although CpG methylation clearly distributes genome-wide in vertebrate nuclear DNA, the
state of methylation in the vertebrate mitochondrial genome has been unclear. Several …

DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular
mechanisms connecting DNA methylation patterns and enzyme activity remain elusive …

The emerging field of epigenomics has the potential to bridge the gap between static
genomic sequences and complex phenotypes that arise from multigenic, nonlinear and …