In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

Single-cell and spatial transcriptomic technologies have revealed an underappreciated
heterogeneity of liver macrophages. This has led us to rethink the involvement of …

An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

Iron is a critical metal for several vital biological processes. Most of the body's iron is bound
to hemoglobin in erythrocytes. Iron from senescent red blood cells is recycled by …

Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of
intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

200 billion red blood cells (RBCs) are produced every day, requiring more than 2× 10 15
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …

Significance: Iron and oxygen are intimately linked: iron is an essential nutrient utilized as a
cofactor in enzymes for oxygen transport, oxidative phosphorylation, and metabolite …

In this study, we detail a novel approach that combines bacterial fitness fluorescent reporter
strains with scRNA-seq to simultaneously acquire the host transcriptome, surface marker …

Many past and recent advances in the field of iron metabolism have relied upon the
discovery of divalent metal transporter 1, DMT1 in 1997. DMT1 is the major iron transporter …