Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

Membrane proteins are involved in numerous vital biological processes, including transport,
signal transduction and the enzymes in a variety of metabolic pathways. Integral membrane …

Enzymes are complex biological catalysts and are critical to life. Most oxidations of
chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize …

Heme-copper oxidases (HCOs) are terminal enzymes on the mitochondrial or bacterial
respiratory electron transport chain, which utilize a unique heterobinuclear active site to …

Oxidative stress (OS) is a condition that occurs as a result of an imbalance between the
production of reactive oxygen species (ROS) and the body's ability to detoxify and neutralize …

The P450 enzyme CYP121 from Mycobacterium tuberculosis catalyzes a carbon–carbon (C–
C) bond coupling cyclization of the dityrosine substrate containing a diketopiperazine ring …

CYP17A1 is an enzyme that plays a major role in steroidogenesis and is critically involved in
the biosynthesis of steroid hormones. Therefore, it remains an attractive target in several …

The cytochrome P450 (CYP) superfamily of heme monooxygenases has demonstrated
ability to facilitate hydroxylation, desaturation, sulfoxidation, epoxidation, heteroatom …

All aspects of prostate cancer evolution are closely related to androgen levels and the status
of the androgen receptor (AR). Almost all treatments target androgen metabolism pathways …

Cytochrome P450 enzymes in the human body play a pivotal role in both the biosynthesis
and the degradation of the hormone melatonin. Melatonin plays a key role in circadian …