Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding
functions that participate in regulation of cell fate in a wide range of cellular systems and are …

Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

Although mass spectrometry is well suited to identifying thousands of potential protein post-
translational modifications (PTMs), it has historically been biased towards just a few. To …

MicroRNAs (miRNA) are non-coding RNAs, approximately 22 nucleotides in length, which
function as post-transcriptional regulators. A large body of evidence indicates that miRNAs …

Transglutaminase 2 (TG2) is a multi-domain, multi-functional enzyme that post-
translationally modifies proteins by catalyzing the formation of intermolecular isopeptide …

Metastasis of primary tumors to distant sites and their inherent or acquired resistance to
currently available therapies pose major clinical challenge to the successful treatment of …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive neoplastic
diseases and is virtually incurable. The molecular mechanisms that contribute to the intrinsic …

Abstract Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that
catalyzes Ca (2+)-dependent protein modifications. In addition to being an enzyme, TG2 …

Recent studies indicate that cancer cells express elevated levels of type II transglutaminase
(TG2), and that expression is further highly enriched in cancer stem cells derived from these …

Background Previous studies have revealed the critical role of transglutaminase 2 (TGM2)
as a potential therapeutic target in cancers, but the oncogenic roles and underlying …