Metal-catalyzed regiodivergent organic reactions

C Nájera, IP Beletskaya, M Yus - Chemical Society Reviews, 2019 - pubs.rsc.org
Metal-catalyzed regiodivergent reactions allow control over regioselectivity in the synthesis
of a wide range of organic products. Starting from the same material, it is possible to prepare …

Recent advances in indazole-containing derivatives: synthesis and biological perspectives

SG Zhang, CG Liang, WH Zhang - Molecules, 2018 - mdpi.com
Indazole-containing derivatives represent one of the most important heterocycles in drug
molecules. Diversely substituted indazole derivatives bear a variety of functional groups and …

Palladium/Norbornene‐Catalyzed Direct Vicinal Di‐Carbo‐Functionalization of Indoles: Reaction Development and Mechanistic Study

X Liu, Y Zhou, X Qi, R Li, P Liu… - Angewandte Chemie …, 2023 - Wiley Online Library
Methods that can simultaneously install multiple different functional groups to heteroarenes
via C− H functionalizations are valuable for complex molecule synthesis, which, however …

Transition-Metal-Catalyzed Divergent C–H Functionalization of Five-Membered Heteroarenes

S Jeong, JM Joo - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Conversion of common reactants to diverse products is a key objective of
organic syntheses. Recent developments in transition-metal-catalyzed C–H functionalization …

A review on synthetic strategy, molecular pharmacology of indazole derivatives, and their future perspective

S Mal, U Malik, M Mahapatra, A Mishra… - Drug Development …, 2022 - Wiley Online Library
With different nitrogen‐containing heterocyclic moieties, Indazoles earn one of the places
among the top investigated molecules in medicinal research. Indazole, an important fused …

Dual ligand approach increases functional group tolerance in the Pd-catalysed C–H arylation of N-heterocyclic pharmaceuticals

I Beckers, A Bugaev, D De Vos - Chemical Science, 2023 - pubs.rsc.org
The excellent functional group tolerance of the Suzuki–Miyaura cross-coupling reactions
has been decisive for their success in the pharmaceutical industry. Highly diversified …

Transition-metal-catalyzed C–H functionalization of pyrazoles

E Kang, HT Kim, JM Joo - Organic & Biomolecular Chemistry, 2020 - pubs.rsc.org
This review describes recent advances in transition-metal-catalyzed C–H functionalization
reactions of pyrazoles to form new C–C and C–heteroatom bonds on the pyrazole ring. In …

Synthesis of Bidentate Nitrogen Ligands by Rh-Catalyzed C–H Annulation and Their Application to Pd-Catalyzed Aerobic C–H Alkenylation

HT Kim, E Kang, M Kim, JM Joo - Organic Letters, 2021 - ACS Publications
A new class of bidentate ligands was prepared by a modular approach involving Rh-
catalyzed C–H annulation reactions. The resulting conformationally constrained ligands …

Zinc‐Catalyzed Asymmetric Formal [4+3] Annulation of Isoxazoles with Enynol Ethers by 6π Electrocyclization: Stereoselective Access to 2H‐Azepines

XQ Zhu, ZS Wang, BS Hou, HW Zhang… - Angewandte Chemie …, 2020 - Wiley Online Library
Abstract 6π electrocyclization has attracted interest in organic synthesis because of its high
stereospecificity and atom economy in the construction of versatile 5–7‐membered cycles …

Metal-Free Boron-Mediated ortho-C–H Hydroxylation of N-Benzyl-3,4,5-tribromopyrazoles

G Wu, Z Yang, X Xu, L Hao, L Chen, Y Wang… - Organic Letters, 2022 - ACS Publications
A novel route has been reported for C–H hydroxylation of benzyl compounds directed by a
3, 4, 5-tribromopyrazole auxiliary via boronation/oxidation using BBr3 and NaBO3· 4H2O …