Challenges of development and implementation of point of care pharmacogenetic testing
SB Haga - Expert review of molecular diagnostics, 2016 - Taylor & Francis
Introduction: Just as technology was the underlying driver of the sequencing of the human
genome and subsequent generation of volumes of genome sequence data from healthy and …
genome and subsequent generation of volumes of genome sequence data from healthy and …
Role of serum level and genetic variation of IL-28B in interferon responsiveness and advanced liver disease in chronic hepatitis C patients
Abstract Interleukin-28B (IL-28B) is suspected to be associated with response to treatment
and one of the basic immunological backgrounds in liver transplant candidate (LTC). We …
and one of the basic immunological backgrounds in liver transplant candidate (LTC). We …
IL28B gene polymorphism rs12979860, but not rs8099917, contributes to the occurrence of chronic HCV infection in Uruguayan patients
N Echeverría, D Chiodi, P López, A Sanchez Ciceron… - Virology journal, 2018 - Springer
Background Host single-nucleotide polymorphisms (SNPs) near the interleukin 28B (IL28B)
locus are associated with sustained virological response to antiviral therapy and with …
locus are associated with sustained virological response to antiviral therapy and with …
[HTML][HTML] Comparison of three different methods for detection of IL28 rs12979860 polymorphisms as a predictor of treatment outcome in patients with hepatitis C virus
Objectives This study aimed to evaluate the specificity, sensitivity, cost, and turn-around time
of three methods of gene polymorphism analysis and to study the relationship between …
of three methods of gene polymorphism analysis and to study the relationship between …
Polymorphism in interferon λ3/interleukin‐28B gene and risk to noncirrhotic chronic hepatitis C genotype 3 virus infection and its effect on the response to combined …
AJ Khan, VA Saraswat, P Ranjan… - Journal of medical …, 2019 - Wiley Online Library
Hepatitis C virus (HCV) infection is a considerable public‐health problem and an important
cause of liver disease with about 71 million people infected worldwide and more than 399 …
cause of liver disease with about 71 million people infected worldwide and more than 399 …
[HTML][HTML] Distribution of IL28B genotypes in Iranian patients with chronic hepatitis C and healthy individuals
H Sharafi, A Pouryasin, SM Alavian, B Behnava… - Hepatitis …, 2012 - ncbi.nlm.nih.gov
Background IL28B polymorphism is recognized as one of the most prominent predictors of
hepatitis C spontaneous and treatment-induced clearance. Interestingly, the favorable …
hepatitis C spontaneous and treatment-induced clearance. Interestingly, the favorable …
[HTML][HTML] Interferon-λ polymorphisms and response to pegylated interferon in Iranian hepatitis C patients
A Haj-Sheykholeslami, M Keshvari… - World Journal of …, 2015 - ncbi.nlm.nih.gov
AIM: To evaluate the efficacy of pegylated interferon in Iranian chronic hepatitis C patients in
relation to interferon-λ (IFNL) polymorphisms. METHODS: This study enrolled patients with …
relation to interferon-λ (IFNL) polymorphisms. METHODS: This study enrolled patients with …
[PDF][PDF] High resolution melting curve assay for detecting rs12979860 IL28B polymorphisms involved in response of Iranian patients to chronic hepatitis C treatment
A Fateh, MR Aghasadeghi… - … Pacific Journal of …, 2015 - pdfs.semanticscholar.org
Background: A recent genome-wide association study (GWAS) on patients with chronic
hepatitis C (CHC) treated with peginterferon and ribavirin (pegIFN-α/RBV) identified a single …
hepatitis C (CHC) treated with peginterferon and ribavirin (pegIFN-α/RBV) identified a single …
[HTML][HTML] Strategies for serum chemokine/cytokine assessment as biomarkers of therapeutic response in HCV patients as a prototype to monitor immunotherapy of …
EG Menezes, JGA Coelho-dos-Reis, LM Cardoso… - Antiviral research, 2017 - Elsevier
In this study, strategies for serum biomarker assessment were developed for therapeutic
monitoring of HCV patients. For this purpose, serum chemokine/cytokine levels were …
monitoring of HCV patients. For this purpose, serum chemokine/cytokine levels were …
[HTML][HTML] The role of polymorphisms near the IL28B gene on response to peg-interferon and ribavirin in thalassemic patients with hepatitis C
B Behnava, H Sharafi, M Keshvari, A Pouryasin… - Hepatitis …, 2016 - ncbi.nlm.nih.gov
Background Hepatitis C Virus (HCV) is the major cause of liver failure in thalassemic
patients. In these patients, iron overload and their comorbidities make difficulties during …
patients. In these patients, iron overload and their comorbidities make difficulties during …