Reprogramming Müller glia to regenerate retinal neurons

M Lahne, M Nagashima, DR Hyde… - Annual Review of …, 2020 - annualreviews.org
In humans, various genetic defects or age-related diseases, such as diabetic retinopathies,
glaucoma, and macular degeneration, cause the death of retinal neurons and profound …

Müller glial cell‐dependent regeneration of the neural retina: An overview across vertebrate model systems

A Hamon, JE Roger, XJ Yang… - Developmental …, 2016 - Wiley Online Library
Retinal dystrophies are a major cause of blindness for which there are currently no curative
treatments. Transplantation of stem cell‐derived neuronal progenitors to replace lost cells …

Müller glia-mediated retinal regeneration

H Gao, X Huang, XI Chen, H Xu - Molecular neurobiology, 2021 - Springer
Müller glia originate from neuroepithelium and are the principal glial cells in the retina.
During retinal development, Müller glia are one of the last cell types to be born. In lower …

The chick eye in vision research: An excellent model for the study of ocular disease

CE Wisely, JA Sayed, H Tamez, C Zelinka… - Progress in retinal and …, 2017 - Elsevier
The domestic chicken, Gallus gallus, serves as an excellent model for the study of a wide
range of ocular diseases and conditions. The purpose of this manuscript is to outline some …

Comparative biology of vertebrate retinal regeneration: restoration of vision through cellular reprogramming

L Todd, TA Reh - Cold Spring Harbor Perspectives in …, 2022 - cshperspectives.cshlp.org
The regenerative capacity of the vertebrate retina varies substantially across species.
Whereas fish and amphibians can regenerate functional retina, mammals do not. In this …

NF-κB signaling regulates the formation of proliferating Müller glia-derived progenitor cells in the avian retina

I Palazzo, K Deistler, TV Hoang, S Blackshaw… - …, 2020 - journals.biologists.com
Retinal regeneration is robust in some cold-blooded vertebrates, but this process is
ineffective in warm-blooded vertebrates. Understanding the mechanisms that suppress the …

Midkine is neuroprotective and influences glial reactivity and the formation of Müller glia‐derived progenitor cells in chick and mouse retinas

WA Campbell, A Fritsch‐Kelleher, I Palazzo, T Hoang… - Glia, 2021 - Wiley Online Library
Recent studies suggest midkine (MDK) is involved in the development and regeneration of
the zebrafish retina. We investigate the expression patterns of MDK and related factors, roles …

Cannabinoid signaling promotes the de‐differentiation and proliferation of Müller glia‐derived progenitor cells

WA Campbell, S Blum, A Reske, T Hoang… - Glia, 2021 - Wiley Online Library
Endocannabinoids (eCB) are lipid‐based neurotransmitters that are known to influence
synaptic function in the visual system. eCBs are also known to suppress neuroinflammation …

Jak/Stat signaling regulates the proliferation and neurogenic potential of Müller glia-derived progenitor cells in the avian retina

L Todd, N Squires, L Suarez, AJ Fischer - Scientific Reports, 2016 - nature.com
Müller glia are capable of de-differentiating and proliferating to become Müller glia-derived
progenitor cells (MGPCs) with the ability to regenerate retinal neurons. One of the cell …

Patterns of NFkB activation resulting from damage, reactive microglia, cytokines, and growth factors in the mouse retina

I Palazzo, L Kelly, L Koenig, AJ Fischer - Experimental neurology, 2023 - Elsevier
Müller glia are a cellular source for neuronal regeneration in vertebrate retinas. However,
the capacity for retinal regeneration varies widely across species. Understanding the …