Beyond BRCA: new hereditary breast cancer susceptibility genes
P Economopoulou, G Dimitriadis, A Psyrri - Cancer treatment reviews, 2015 - Elsevier
Abstract Approximately 5–10% of breast cancer cases might be inheritable, up to 30% of
which are due to BRCA1/2 mutations. During the past few years and thanks to technology …
which are due to BRCA1/2 mutations. During the past few years and thanks to technology …
The ATM gene in breast cancer: Its relevance in clinical practice
LS Stucci, V Internò, M Tucci, M Perrone, F Mannavola… - Genes, 2021 - mdpi.com
Molecular alterations of the Ataxia-telangiectasia (AT) gene are frequently detected in breast
cancer (BC), with an incidence ranging up to 40%. The mutated form, the Ataxia …
cancer (BC), with an incidence ranging up to 40%. The mutated form, the Ataxia …
Prognostic biomarkers in uveal melanoma: The status quo, recent advances and future directions
NJ Lamas, A Martel, S Nahon-Estève, S Goffinet… - Cancers, 2021 - mdpi.com
Simple Summary Although rare, uveal melanoma (UM) is the most common cancer that
develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal …
develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal …
[HTML][HTML] MicroRNA-421 regulated by HIF-1α promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric …
X Ge, X Liu, F Lin, P Li, K Liu, R Geng, C Dai, Y Lin… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Hypoxia and dysregulation of microRNAs (miRNAs) have been identified as crucial factors
in carcinogenesis. However, the potential mechanisms of HIF-1α and miR-421 in gastric …
in carcinogenesis. However, the potential mechanisms of HIF-1α and miR-421 in gastric …
Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines
E Kubota, CT Williamson, R Ye, A Elegbede… - Cell cycle, 2014 - Taylor & Francis
Small-molecule inhibitors of poly (ADP-ribose) polymerase (PARP) have shown
considerable promise in the treatment of homologous recombination (HR)-defective tumors …
considerable promise in the treatment of homologous recombination (HR)-defective tumors …
[HTML][HTML] CircAHNAK1 inhibits proliferation and metastasis of triple-negative breast cancer by modulating miR-421 and RASA1
W Xiao, S Zheng, Y Zou, A Yang, X Xie, H Tang… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Background: There is increasing evidence that circular RNAs (circRNAs) participate in
regulating cancer progression. However, the function and potential molecular mechanisms …
regulating cancer progression. However, the function and potential molecular mechanisms …
Cyclin-dependent kinase 4/6 inhibitor outcomes in patients with advanced breast cancer carrying germline pathogenic variants in DNA repair–related genes
L Bruno, A Ostinelli, F Waisberg, D Enrico… - JCO Precision …, 2022 - ascopubs.org
PURPOSE In recent years, unprecedented benefits have been observed with the
development of cyclin-dependent kinase (CDK) 4 and 6 inhibitors for the treatment of …
development of cyclin-dependent kinase (CDK) 4 and 6 inhibitors for the treatment of …
Clinico-genomic Characterization of ATM and HRD in Pancreas Cancer: Application for Practice
Purpose: Characterizing germline and somatic ATM variants (g ATM m, s ATM m) zygosity
and their contribution to homologous recombination deficiency (HRD) is important for …
and their contribution to homologous recombination deficiency (HRD) is important for …
ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA …
S Rondeau, S Vacher, L De Koning, A Briaux… - British journal of …, 2015 - nature.com
Background: Ataxia telangiectasia mutated (ATM) is a kinase that has a central role in the
maintenance of genomic integrity by activating cell cycle checkpoints and promoting repair …
maintenance of genomic integrity by activating cell cycle checkpoints and promoting repair …
MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3
Y Cheng, J Mai, T Hou, J Ping - Biochemical and Biophysical Research …, 2016 - Elsevier
Background and aim Mitochondrial dysfunction plays a major role in critical initiating or
propagating events in nonalcoholic fatty liver disease (NAFLD), but its pathogenesis …
propagating events in nonalcoholic fatty liver disease (NAFLD), but its pathogenesis …