Modern neuropsychopharmacology commenced in the 1950s with the serendipitous
discovery of first-generation antipsychotics and antidepressants which were therapeutically …

Background Joint models for longitudinal and time-to-event data are commonly used to
simultaneously analyse correlated data in single study cases. Synthesis of evidence from …

Nonlinear joint models are a powerful tool to precisely analyse the association between a
nonlinear biomarker and a time‐to‐event process, such as death. Here, we review the main …

Importance Facilitating the development of safe and effective medications for schizophrenia
is a public health imperative. Objectives To evaluate the association of shortening …

In order to accelerate drug development and avoid unnecessary drug trials in vulnerable
pediatric populations, the US Food and Drug Administration (FDA) released a general …

The aim of this study was to investigate the characteristics of cognitive function damage in
chronic schizophrenia patients with metabolic syndrome (MS); 388 patients were divided …

Aims A new, long‐acting, subcutaneous (SC) formulation of risperidone (RBP‐7000) has
been developed for the treatment of schizophrenia to address issues of non‐adherence …

As biomarkers are lacking, multi‐item questionnaire‐based tools like the Positive and
Negative Syndrome Scale (PANSS) are used to quantify disease severity in schizophrenia …

Considerable research has been conducted seeking risk factors and constructing prediction
models for transition to psychosis in individuals at ultra-high risk (UHR). Nearly all such …

The neuroimaging mechanisms that arise in patients with schizophrenia and comorbid
metabolic syndrome (MetS) remain poorly understood. This study was devised to examine …