The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …

Parkinson's disease (PD) is the second most common neurodegenerative disease. PD
patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural …

Neuroinflammation is one of the most important processes involved in the pathogenesis of
Parkinson's disease (PD). The current concept of neuroinflammation comprises an …

Neurotrophic factors play a key role in development, differentiation, synaptogenesis, and
survival of neurons in the brain as well as in the process of their adaptation to external …

In the central nervous system (CNS) there are a greater number of glial cells than neurons
(between five and ten times more). Furthermore, they have a greater number of functions …

The endoplasmic reticulum (ER) is the largest organelle of the cell, composed of a
continuous network of sheets and tubules, and is involved in protein, calcium (Ca 2+), and …

In this study we report on a surface acoustic wave (SAW) sensor modified with a molecularly
imprinted polymer (MIP) film that selectively recognizes the cerebral dopamine neurotrophic …

Background Extracellular accumulation of amyloid β-peptide (Aβ) is one of pathological
hallmarks of Alzheimer's disease (AD) and contributes to the neuronal loss. Mesencephalic …

Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine
neurotrophic factor (CDNF) are endoplasmic reticulum (ER) luminal proteins that confer …

The conserved mesencephalic astrocyte-derived neurotrophic factor (MANF) is known for
protecting dopaminergic neurons and functioning in various other tissues. Previously, we …