From its earliest observation as an unusual reaction only a half century ago, 1 the insertion
of a carbene into a carbonrhydrogen bond has attracted considerable interest because of its …

γ-Butenolides, γ-butyrolactones, and derivatives, especially in enantiomerically pure form,
constitute the structural core of numerous natural products which display an impressive …

Strategies for the total synthesis of complex natural products that contain two or more
contiguous stereogenic quaternary carbon atoms in their intricate structures are reviewed …

Organic chemists have always been fascinated by the cyclopropane subunit. 1 The smallest
cycloalkane is found as a basic structural element in a wide range of naturally occurring …

A long‐standing challenge to synthesis can now be met through the use of new and
powerful catalytic asymmetric reactions for the assembly of complex chiral molecules with …

Practical asymmetric catalysis using transition metal complexes was inspired by the work of
Kagan1 and Knowles. 2 Their important results, based on the use of chiral phosphines as …

While the cyclopropane ring is a highly strained entity, it is nonetheless found in a wide
variety of naturally occurring compounds including terpenes, pheromones, fatty acid …

The rhodium N-(arylsulfonyl) prolinate catalyzed decomposition of vinyldiazomethanes in
the presence of alkenes leads to a very general method for the synthesis of functionalized …

The metal‐catalyzed decomposition of diazo compounds in the presence of alkenes is a
well‐established reaction. Since the original Organic Reactions review on the reaction of …

Almost 30 years after Emschwiller prepared IZnCH2I, Simmons and Smith discovered that
the reagent formed by mixing a zinc‐copper couple with CH2I2 in ether could be used for …