Family of melanocortin receptor (MCR) genes in mammals—mutations, polymorphisms and phenotypic effects

M Switonski, M Mankowska, S Salamon - Journal of applied genetics, 2013 - Springer
The melanocortin receptor gene family consists of five single-exon members, which are
located on autosomes. Three genes (MC2R, MC4R and MC5R) are syntenic in the human …

ACTH receptor (MC2R) specificity: what do we know about underlying molecular mechanisms?

D Fridmanis, A Roga, J Klovins - Frontiers in Endocrinology, 2017 - frontiersin.org
Coincidentally, the release of this Research Topic in Frontiers in Endocrinology takes place
25 years after the discovery of the adrenocorticotropic hormone receptor (ACTHR) by …

Genetic architecture and selection of Anhui autochthonous pig population revealed by whole genome resequencing

W Zhang, X Li, Y Jiang, M Zhou, L Liu, S Su, C Xu… - Frontiers in …, 2022 - frontiersin.org
The genetic resources among pigs in Anhui Province are diverse, but their value and
potential have yet to be discovered. To illustrate the genetic diversity and population …

[HTML][HTML] Comparative transcriptomic analysis of high and low egg-producing duck ovaries

Z Tao, W Song, C Zhu, W Xu, H Liu, S Zhang, L Huifang - Poultry Science, 2017 - Elsevier
The egg-laying rate is an important indicator of egg production of laying ducks. Egg
production directly impacts the economic benefits of the duck industry. In order to obtain …

Intracellular signaling mechanisms of the melanocortin receptors: current state of the art

AR Rodrigues, H Almeida, AM Gouveia - Cellular and Molecular Life …, 2015 - Springer
The melanocortin system is composed by the agonists adrenocorticotropic hormone and α, β
and γ-melanocyte-stimulating hormone, and two naturally occurring antagonists, agouti and …

Development of melanoma-targeted polymer micelles by conjugation of a melanocortin 1 receptor (MC1R) specific ligand

NM Barkey, NK Tafreshi, JS Josan… - Journal of medicinal …, 2011 - ACS Publications
The incidence of malignant melanoma is rising faster than that of any other cancer in the
United States. Because of its high expression on the surface of melanomas, MC1R has been …

Signatures of selection in Angus and Hanwoo beef cattle using imputed whole genome sequence data

MY Nawaz, RP Savegnago, D Lim, SH Lee… - Frontiers in …, 2024 - frontiersin.org
In this study, we detected signatures of selection in Hanwoo and Angus beef cattle using
allele frequency and haplotype-based methods based on imputed whole genome sequence …

Role of ACTH in the interactive/paracrine regulation of adrenal steroid secretion in physiological and pathophysiological conditions

H Lefebvre, M Thomas, C Duparc, J Bertherat… - Frontiers in …, 2016 - frontiersin.org
In the normal human adrenal gland, steroid secretion is regulated by a complex network of
autocrine/paracrine interactions involving bioactive signals released by endothelial cells …

Study on the mechanism of MC5R participating in energy metabolism of goose liver

J Zhang, Y Xing, F Li, J Mu, T Liu, J Ge, M Zhao… - International Journal of …, 2023 - mdpi.com
Nutrition and energy levels have an important impact on animal growth, production
performance, disease occurrence and health recovery. Previous studies indicate that …

α-MSH signalling via melanocortin 5 receptor promotes lipolysis and impairs re-esterification in adipocytes

AR Rodrigues, H Almeida, AM Gouveia - Biochimica et Biophysica Acta …, 2013 - Elsevier
The melanocortin system has a clear effect on the mobilisation of stored lipids in adipocytes.
The aim of the current study was to investigate the role of melanocortin 5 receptor (MC5R) …