Molecular profiling in non-squamous non-small cell lung carcinoma: towards a switch to next-generation sequencing reflex testing

N Pujol, S Heeke, C Bontoux, J Boutros, M Ilie… - Journal of Personalized …, 2022 - mdpi.com
Molecular diagnosis of lung cancer is a constantly evolving field thanks to major advances in
precision oncology. The wide range of actionable molecular alterations in non-squamous …

Updates in pathology and molecular diagnostics to inform the evolving landscape of thoracic surgery and oncology

J Naso, YC Lo, LM Sholl - Journal of Surgical Oncology, 2023 - Wiley Online Library
The pathologic assessment of lung cancers provides essential guidance to the surgeon and
oncologist who are considering the best treatment strategies for patients with both early and …

Clinical utility and performance of an ultrarapid multiplex RNA-based assay for detection of ALK, ROS1, RET, and NTRK1/2/3 rearrangements and MET exon 14 …

YH Chu, J Barbee, SR Yang, JC Chang, P Liang… - The Journal of Molecular …, 2022 - Elsevier
Several kinase fusions are established targetable drivers in lung cancers. However, rapid
and comprehensive detection remains challenging because of diverse partner genes and …

FACILITATE: A real-world, multicenter, prospective study investigating the utility of a rapid, fully automated real-time PCR assay versus local reference methods for …

A Behnke, A Cayre, G De Maglio… - Pathology and …, 2023 - por-journal.com
Accurate testing for epidermal growth factor receptor (EGFR) variants is essential for
informing treatment decisions in non-small cell lung cancer (NSCLC). Automated diagnostic …

Contribution of the IdyllaTM System to Improving the Therapeutic Care of Patients with NSCLC through Early Screening of EGFR Mutations

C Petiteau, G Robinet-Zimmermann, A Riot… - Current …, 2021 - mdpi.com
Epidermal growth factor receptor (EGFR) genotyping, a critical examen for the treatment
decisions of patients with non-small cell lung cancer (NSCLC), is commonly assayed by next …

Utility of select gene mutation detection in tumors by the Idylla rapid multiplex PCR platform in comparison to next-generation sequencing

D Nkosi, VL Casler, CR Syposs, ZN Oltvai - Genes, 2022 - mdpi.com
Testing of tumors by next generation sequencing (NGS) is impacted by relatively long
turnaround times and a need for highly trained personnel. Recently, Idylla oncology assays …

[HTML][HTML] Percutaneous image-guided biopsy for a comprehensive hybridization capture-based next-generation sequencing in primary lung cancer: safety, efficacy, and …

A Elsakka, EN Petre, F Ridouani, M Ghosn… - JTO Clinical and …, 2022 - Elsevier
Introduction To evaluate factors associated with successful comprehensive genomic
sequencing of image-guided percutaneous needle biopsies in patients with lung cancer …

Idylla EGFR assay on extracted DNA: Advantages, limits and place in molecular screening according to the latest guidelines for non-small-cell lung cancer (NSCLC) …

E Khalifa, C Chapusot, B Tournier, J Sentis… - Journal of Clinical …, 2023 - jcp.bmj.com
Aims Idylla epidermal growth factor receptor (EGFR) is a fast and fully automated mutation
assay that is easy to implement. However, under the Biocartis-recommended technical …

Evaluation of the Idylla ctEGFR mutation assay to detect EGFR mutations in plasma from patients with non-small cell lung cancers

P Gilson, C Saurel, J Salleron, M Husson… - Scientific Reports, 2021 - nature.com
The assessment of EGFR mutations is recommended for the management of patients with
non-small cell lung cancer (NSCLC). Presence of EGFR mutation is associated with …

The association of EGFR amplification with aberrant exon 20 insertion report using the cobas EGFR Mutation Test v2

MS Zhang, YC Yeh, HN Huang, LW Lin, YL Huang… - Plos one, 2024 - journals.plos.org
Determining the exact type of epidermal growth factor receptor (EGFR) exon 20 insertion
(ex20ins) mutation in lung cancer has become important. We found that not all ex20ins …