An overview of glycosylation and its impact on cardiovascular health and disease

KJ Loaeza-Reyes, E Zenteno… - Frontiers in molecular …, 2021 - frontiersin.org
The cardiovascular system is a complex and well-organized system in which glycosylation
plays a vital role. The heart and vascular wall cells are constituted by an array of specific …

Proteomics of extracellular vesicles: update on their composition, biological roles and potential use as diagnostic tools in atherosclerotic cardiovascular diseases

A Mallia, E Gianazza, B Zoanni, M Brioschi, SS Barbieri… - Diagnostics, 2020 - mdpi.com
Extracellular vesicles (EVs) are lipid-bound vesicles released from cells under physiological
and pathological conditions. Basing on biogenesis, dimension, content and route of …

Exosomes in cardiovascular disease: from mechanism to therapeutic target

AB Reiss, S Ahmed, M Johnson, U Saeedullah… - Metabolites, 2023 - mdpi.com
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. In
recent decades, clinical research has made significant advances, resulting in improved …

Mitochondrial chaperones in human health and disease

T Bahr, J Katuri, T Liang, Y Bai - Free Radical Biology and Medicine, 2022 - Elsevier
Molecular chaperones are a family of proteins that maintain cellular protein homeostasis
through non-covalent peptide folding and quality control mechanisms. The chaperone …

Cardiolipin regulates mitochondrial ultrastructure and function in mammalian cells

Z Jiang, T Shen, H Huynh, X Fang, Z Han, K Ouyang - Genes, 2022 - mdpi.com
Cardiolipin (CL) is a unique, tetra-acylated diphosphatidylglycerol lipid that mainly localizes
in the inner mitochondria membrane (IMM) in mammalian cells and plays a central role in …

Two decades of vaccine development against atherosclerosis

MA Moreno-Gonzalez, OA Ortega-Rivera… - Nano today, 2023 - Elsevier
Atherosclerosis is an immune-mediated chronic inflammatory disease that leads to the
development of fatty plaques in the arterial walls, ultimately increasing the risk of thrombosis …

HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis

C Cömert, K Kjær-Sørensen, J Hansen, J Carlsen… - Molecular …, 2024 - Elsevier
Objective Mitochondrial proteostasis is critical for cellular function. The molecular chaperone
HSP60 is essential for cell function and dysregulation of HSP60 expression has been …

Effect of whole-body resistance training at different load intensities on circulating inflammatory biomarkers, body fat, muscular strength, and physical performance in …

MAS Carneiro, GN Oliveira Júnior… - Applied Physiology …, 2021 - cdnsciencepub.com
The primary purpose of this study was to identify the impact of whole-body resistance
training (RT) at different load intensities on adipokines, adhesion molecules, and …

The role of heat shock proteins in the pathogenesis of heart failure

AP Sklifasovskaya, M Blagonravov… - International …, 2023 - spandidos-publications.com
The influence of heat shock proteins (HSPs) on protein quality control systems in
cardiomyocytes is currently under investigation. The effect of HSPs on the regulated cell …

Host cell stress response as a predictor of COVID-19 infectivity and disease progression

C Caillet, ML Stofberg, V Muleya, A Shonhai… - Frontiers in Molecular …, 2022 - frontiersin.org
The coronavirus disease (COVID-19) caused by a coronavirus identified in December 2019
has caused a global pandemic. COVID-19 was declared a pandemic in March 2020 and has …