Regulatory circular RNAs in viral diseases: applications in diagnosis and therapy
W Wang, L Sun, MT Huang, Y Quan, T Jiang, Z Miao… - RNA biology, 2023 - Taylor & Francis
Circular RNA (circRNA) forms closed loops via back-splicing in precursor mRNA, resisting
exonuclease degradation. In higher eukaryotes, protein-coding genes create circRNAs …
exonuclease degradation. In higher eukaryotes, protein-coding genes create circRNAs …
Transcriptome-based identification of tumor-reactive and bystander CD8+ T cell receptor clonotypes in human pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is generally refractory to immune checkpoint
blockade, although patients with genetically unstable tumors can show modest therapeutic …
blockade, although patients with genetically unstable tumors can show modest therapeutic …
Lysine-derived charge-altering releasable transporters: targeted delivery of mRNA and siRNA to the lungs
TR Blake, OAW Haabeth, A Sallets… - Bioconjugate …, 2023 - ACS Publications
Targeted delivery of nucleic acid therapeutics to the lungs could transform treatment options
for pulmonary disease. We have previously developed oligomeric charge-altering …
for pulmonary disease. We have previously developed oligomeric charge-altering …
Rapid in silico directed evolution by a protein language model with EVOLVEpro
K Jiang, Z Yan, M Di Bernardo, SR Sgrizzi, L Villiger… - Science, 2024 - science.org
Directed protein evolution is central to biomedical applications but faces challenges like
experimental complexity, inefficient multi-property optimization, and local maxima traps …
experimental complexity, inefficient multi-property optimization, and local maxima traps …
Synthetic miR-21 decoy circularized by tRNA splicing mechanism inhibited tumorigenesis in glioblastoma in vitro and in vivo models
Glioblastoma multiforme (GBM) is the deadliest primary central nervous system tumor.
miRNAs (miRs), a class of non-coding RNAs, are considered pivotal post-transcriptional …
miRNAs (miRs), a class of non-coding RNAs, are considered pivotal post-transcriptional …
CircRNA: a rising therapeutic strategy for lung injury induced by pulmonary toxicants
C Liao, ZW He, R Yu, YJ Yu, XR Liu, DL Kong… - Archives of …, 2024 - Springer
Lung injury has been a serious medical problem that requires new therapeutic approaches
and biomarkers. Circular RNAs (circRNAs) are non-coding RNAs (ncRNAs) that exist widely …
and biomarkers. Circular RNAs (circRNAs) are non-coding RNAs (ncRNAs) that exist widely …
Rapid protein evolution by few-shot learning with a protein language model
K Jiang, Z Yan, M Di Bernardo, SR Sgrizzi, L Villiger… - …, 2024 - pmc.ncbi.nlm.nih.gov
Directed evolution of proteins is critical for applications in basic biological research,
therapeutics, diagnostics, and sustainability. However, directed evolution methods are labor …
therapeutics, diagnostics, and sustainability. However, directed evolution methods are labor …
Highly efficient cellular expression of circular mRNA enables prolonged protein expression
MJ Unti, SR Jaffrey - Cell Chemical Biology, 2024 - cell.com
A major problem with mRNA therapeutics is that mRNA is usually degraded within a few
hours after entering the cytosol. New approaches for in vitro synthesis of circular mRNA …
hours after entering the cytosol. New approaches for in vitro synthesis of circular mRNA …
[图书][B] Circular RNAs
C Dieterich, ML Baudet - 2024 - Springer
In the rapidly evolving field of molecular biology, a captivating class of non-coding RNAs has
emerged as a subject of intense research and fascination—Circular RNAs (circRNAs) …
emerged as a subject of intense research and fascination—Circular RNAs (circRNAs) …