How do modifiable risk factors affect Alzheimer's disease pathology or mitigate its effect on clinical symptom expression?

V Ourry, AP Binette, F St-Onge, C Strikwerda-Brown… - Biological …, 2024 - Elsevier
Epidemiological studies show that modifiable risk factors account for approximately 40% of
the population variability in risk of developing dementia, including sporadic Alzheimer's …

Personality associations with amyloid and tau: Results from the Baltimore Longitudinal Study of Aging and meta-analysis

A Terracciano, M Bilgel, D Aschwanden, M Luchetti… - Biological …, 2022 - Elsevier
Background Higher neuroticism and lower conscientiousness are risk factors for Alzheimer's
disease and related dementias, but the underlying neuropathological correlates remain …

The association between personality and plasma biomarkers of astrogliosis and neuronal injury

A Terracciano, K Walker, Y An, M Luchetti… - Neurobiology of …, 2023 - Elsevier
Personality traits have been associated with the risk of dementia and Alzheimer's disease
neuropathology, including amyloid and tau. This study examines whether personality traits …

[HTML][HTML] Association of personality facets and cognition in the Lifelines population-based cohort study

S Marcolini, I Frentz, A Terracciano… - Journal of psychiatric …, 2023 - Elsevier
Background Personality traits have been associated with cognitive functioning and risk of
cognitive decline. Fewer studies have investigated how personality facets are associated …

Personality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta‐analysis

ED Beck, T Yoneda, BD James… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION The extent to which the Big Five personality traits and subjective well‐
being (SWB) are discriminatory predictors of clinical manifestation of dementia versus …

Facets of personality and risk of cognitive impairment: Longitudinal findings in a rural community from Sardinia

A Terracciano, MR Piras, AR Sutin… - Journal of …, 2022 - content.iospress.com
Background: Few studies have examined the associations between personality facets and
dementia risk and rarely included individuals from rural settings or with low education …

Personality impact on Alzheimer's disease—signature and vascular imaging markers: a PET-MRI study

P Giannakopoulos, C Rodriguez… - Journal of …, 2022 - content.iospress.com
Background: Several studies postulated that personality is an independent determinant of
cognitive trajectories in old age. Objective: This study explores the impact of personality on …

Cognitive Outcomes in Autosomal-Dominant Alzheimer's Disease: A Comprehensive Review from a Colombian Kindred with the Presenilin-1 E280A Mutation

A Giudicessi, CP McDowell, JE Martinez… - Journal of …, 2024 - content.iospress.com
Background: The largest identified kindred worldwide with a single mutation causing
autosomal-dominant Alzheimer's disease (ADAD) is a family from Antioquia, Colombia …

Substance use-related cognitive decline in families with autosomal dominant Alzheimer's disease: a cohort study

C Ramos, C Villalba, J García, S Lanata… - Journal of …, 2022 - content.iospress.com
Background: Cigarette smoking is a known risk factor for Alzheimer's disease (AD).
However, the association between neurodegeneration and other substances has not been …