Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major
causes of mortality, since two million people die each year from this malady. TB has many …

Current diagnostic tests for tuberculosis based on tuberculin have poor specificity, and both
BCG vaccination and exposure to non-tuberculosis mycobacteria produce a response …

Mycobacterium avium subsp. paratuberculosis (basonym M. paratuberculosis) is the
etiologic agent of a severe gastroenteritis in ruminants known as Johne's disease. Economic …

A novel immunogenic antigen, the 6-kDa early secretory antigenic target (ESAT-6), from
short-term culture filtrates of Mycobacterium tuberculosis was purified by hydrophobic …

ESAT-6 is a secreted protein present in the short-term culture filtrate of Mycobacterium
tuberculosis after growth on a synthetic Sauton medium. ESAT-6 has recently been …

Mycobacterium tuberculosis (M. tb), the causative agent of tuberculosis (TB), is the current
leading cause of death due to a single infectious organism. Although curable, the broad …

Vaccination remains a key tool in the protection and eradication of diseases. However, the
development of new safe and effective vaccines is not easy. Various live organism based …

Antibodies are an effective line of defense in preventing infectious diseases. Highly potent
neutralizing antibodies can intercept a virus before it attaches to its target cell and, thus …

Proeomics-based approaches, which examine the expressed proteins of a tissue or cell
type, complement the genome initiatives and are increasingly being used to address …

Tuberculosis is the most widespread and lethal infectious disease affecting humans.
Immunization of mice with plasmid DNA constructs encoding one of the secreted …