Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago
and has become a widely used model in the search for antidepressant drugs for major …

This review summarizes all reported and suspected functions of ultrasonic vocalizations in
infant and adult rats. The review leads to the conclusion that all types of ultrasonic …

Simple Summary Scientists use animal models to study the mechanisms of human diseases
and find new drugs to treat them. Chronic Unpredictable Mild Stress is the best animal …

Many mammals have evolved to be social creatures. In humans, the ability to learn from
others' experiences is essential to survival; and from an early age, individuals are …

Many rodent species emit and detect vocalizations in the ultrasonic range. Rats use three
classes of ultrasonic vocalizations depending on developmental stage, experience and the …

Abstract BONAUTO, SM, OM Greuel, and JA Honeycutt. Playback of rat 22-kHz ultrasonic
vocalizations as a translational assay of negative affective states: An analysis of evoked …

Early life adversity (ELA) increases the incidence of later-life anxiety disorders. Dysregulated
threat processing, including responsivity to ambiguous threats, is an indicator of anxiety …

Deficits in processing social signals leads to reduced social functioning and is typically
associated with neuropsychiatric disorders, including autism spectrum disorder …

Although rodents have a well-structured vocal form of communication, like humans and non-
human primates, there is, to date, no evidence for a vocal signature in the well-known 50 …

Highlights•Rodents display diverse social behaviors.•Many social behaviors are supported
by acoustic communication.•Rodent studies are providing insights into the neural circuits …