Mendelian randomization refers to an analytic approach to assess the causality of an
observed association between a modifiable exposure or risk factor and a clinically relevant …

Objectives: The purpose of this study was to estimate the effect of long-term exposure to
lower plasma low-density lipoprotein cholesterol (LDL-C) on the risk of coronary heart …

Admixed populations are routinely excluded from genomic studies due to concerns over
population structure. Here, we present a statistical framework and software package, Tractor …

Genetic association studies, in particular the genome-wide association study (GWAS)
design, have provided a wealth of novel insights into the aetiology of a wide range of human …

Background Familial hypercholesterolaemia is a common autosomal-dominant disorder
caused by mutations in three known genes. DNA-based cascade testing is recommended by …

A decrease in the activity of proprotein convertase subtilisin/kexin type 9 (PCSK9) increases
the amount of low-density lipoprotein (LDL) receptors on liver cells and, therefore, LDL …

Genome-wide association studies (GWASs) have identified many SNPs underlying
variations in plasma-lipid levels. We explore whether additional loci associated with plasma …

To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale
meta-analyses by using a custom∼ 50,000 SNP genotyping array (the ITMAT-Broad-CARe …

Plasma triglyceride (TG) concentration is reemerging as an important cardiovascular
disease risk factor. More complete understanding of the genes and variants that modulate …

Dyslipidemia is a commonly encountered clinical condition and is an important determinant
of cardiovascular disease. Although secondary factors play a role in clinical expression …