[HTML][HTML] An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles

M Baumann, IR Baxendale - Beilstein journal of organic …, 2013 - beilstein-journals.org
This review which is the second in this series summarises the most common synthetic routes
as applied to the preparation of many modern pharmaceutical compounds categorised as …

Natural and synthetic 2H-pyran-2-ones and their versatility in organic synthesis

A Goel, VJ Ram - Tetrahedron, 2009 - Elsevier
The pyran ring system is widely present in the animal and plant kingdom and possesses
diverse pharmacological activities. Pyran is a six-membered oxygen heterocycle with two …

A concise review on some synthetic routes and applications of pyridine scaffold compounds

S Abdel-Raheem, A El-Dean… - Current Chemistry …, 2021 - m.growingscience.com
Different methods for the synthesis of pyridine derivatives as well as the chemical reactivity
profiles and structures of these substances are reviewed. The utility of these compounds as …

Coumarin hybrid derivatives as promising leads to treat tuberculosis: Recent developments and critical aspects of structural design to exhibit anti-tubercular activity

DS Reddy, M Kongot, A Kumar - Tuberculosis, 2021 - Elsevier
Tuberculosis (TB) is a highly contagious airborne disease with nearly 25% of the world's
population infected with it. Challenges such as multi drug resistant TB (MDR-TB), extensive …

Synthesis and evaluation of antifungal properties of a series of the novel 2-amino-5-oxo-4-phenyl-5, 6, 7, 8-tetrahydroquinoline-3-carbonitrile and its analogues

AR Gholap, KS Toti, F Shirazi, R Kumari… - Bioorganic & medicinal …, 2007 - Elsevier
A series of 2-amino-5-oxo-4-phenyl-5, 6, 7, 8-tetrahydroquinoline-3-carbonitrile and various
analogues have been synthesized in excellent isolated yields starting from various …

New arylated benzo[h]quinolines induce anti-cancer activity by oxidative stress-mediated DNA damage

DK Yadav, R Rai, N Kumar, S Singh, S Misra… - Scientific reports, 2016 - nature.com
The anti-cancer activity of the benzo [h] quinolines was evaluated on cultured human skin
cancer (G361), lung cancer (H460), breast cancer (MCF7) and colon cancer (HCT116) cell …

[HTML][HTML] A multicomponent synthesis of 2-amino-3-cyanopyridine derivatives catalyzed by heterogeneous and recyclable copper nanoparticles on charcoal

R Khalifeh, M Ghamari - Journal of the Brazilian Chemical Society, 2016 - SciELO Brasil
An efficient and convenient method was developed for synthesis of 2-amino-3-
cyanopyridine derivatives via the four-component coupling reaction between ketone …

Synthesis of polysubstituted pyridines via a one-pot metal-free strategy

H Wei, Y Li, K Xiao, B Cheng, H Wang, L Hu… - Organic letters, 2015 - ACS Publications
An efficient strategy for the one-pot synthesis of polysubstituted pyridines via a cascade
reaction from aldehydes, phosphorus ylides, and propargyl azide is reported. The reaction …

Structural and spectroscopic studies on 2-pyranones

P Thul, VP Gupta, VJ Ram, P Tandon - Spectrochimica Acta Part A …, 2010 - Elsevier
Experimental methods of infrared, Raman and electronic absorption spectroscopy and DFT
calculations using B3LYP functionals and 6-31G** and 6-311++ G** basis sets have been …

2H-Pyran-2-ones and their annelated analogs as multifaceted building blocks for the fabrication of diverse heterocycles

R Pratap, VJ Ram - Tetrahedron, 2017 - Elsevier
Abstract 2H-Pyran-2-ones are widely present in nature and found as either isolated or in
fused form. Depending on the fusion of benzene ring, pyran can give coumarins …